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A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.
Yan, Helen H N; Siu, Hoi Cheong; Law, Simon; Ho, Siu Lun; Yue, Sarah S K; Tsui, Wai Yin; Chan, Dessy; Chan, April S; Ma, Stephanie; Lam, Ka On; Bartfeld, Sina; Man, Alice H Y; Lee, Bernard C H; Chan, Annie S Y; Wong, Jason W H; Cheng, Priscilla S W; Chan, Anthony K W; Zhang, Jiangwen; Shi, Jue; Fan, Xiaodan; Kwong, Dora L W; Mak, Tak W; Yuen, Siu Tsan; Clevers, Hans; Leung, Suet Yi.
Affiliation
  • Yan HHN; Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong. Electronic address: yanhelen@hku.hk.
  • Siu HC; Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
  • Law S; Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
  • Ho SL; Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
  • Yue SSK; Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
  • Tsui WY; Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
  • Chan D; Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
  • Chan AS; Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
  • Ma S; School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.
  • Lam KO; Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
  • Bartfeld S; Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, Utrecht, the Netherlands.
  • Man AHY; Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
  • Lee BCH; Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
  • Chan ASY; Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
  • Wong JWH; School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.
  • Cheng PSW; Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
  • Chan AKW; Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
  • Zhang J; School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong.
  • Shi J; Department of Biology and Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
  • Fan X; Department of Statistics, Chinese University of Hong Kong, Shatin, Hong Kong.
  • Kwong DLW; Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
  • Mak TW; Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
  • Yuen ST; Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong; Department of Pathology, St. Paul's Hospital, No. 2, Eastern Hospital Road, Causeway Bay, Hong Kong.
  • Clevers H; Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, Utrecht, the Netherlands; Princess Maxima Center for Pediatric Oncology, 3584 CT Utrecht, the Netherlands.
  • Leung SY; Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong; The Jockey Club Centre for Clinical Innovation and Discovery, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong. Electronic address: suetyi@hku.hk.
Cell Stem Cell ; 23(6): 882-897.e11, 2018 12 06.
Article in En | MEDLINE | ID: mdl-30344100
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Drug Screening Assays, Antitumor / Organoids / Biological Specimen Banks / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Female / Humans / Male Language: En Journal: Cell Stem Cell Year: 2018 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Drug Screening Assays, Antitumor / Organoids / Biological Specimen Banks / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Female / Humans / Male Language: En Journal: Cell Stem Cell Year: 2018 Type: Article