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Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
Haile, Pamela A; Casillas, Linda N; Bury, Michael J; Mehlmann, John F; Singhaus, Robert; Charnley, Adam K; Hughes, Terry V; DeMartino, Michael P; Wang, Gren Z; Romano, Joseph J; Dong, Xiaoyang; Plotnikov, Nikolay V; Lakdawala, Ami S; Convery, Maire A; Votta, Bartholomew J; Lipshutz, David B; Desai, Biva M; Swift, Barbara; Capriotti, Carol A; Berger, Scott B; Mahajan, Mukesh K; Reilly, Michael A; Rivera, Elizabeth J; Sun, Helen H; Nagilla, Rakesh; LePage, Carol; Ouellette, Michael T; Totoritis, Rachel D; Donovan, Brian T; Brown, Barry S; Chaudhary, Khuram W; Gough, Peter J; Bertin, John; Marquis, Robert W.
Affiliation
  • Haile PA; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Casillas LN; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Bury MJ; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Mehlmann JF; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Singhaus R; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Charnley AK; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Hughes TV; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • DeMartino MP; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Wang GZ; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Romano JJ; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Dong X; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Plotnikov NV; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Lakdawala AS; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Convery MA; GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Votta BJ; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Lipshutz DB; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Desai BM; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Swift B; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Capriotti CA; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Berger SB; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Mahajan MK; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Reilly MA; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Rivera EJ; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Sun HH; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Nagilla R; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • LePage C; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Ouellette MT; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Totoritis RD; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Donovan BT; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Brown BS; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Chaudhary KW; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Gough PJ; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Bertin J; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Marquis RW; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.
ACS Med Chem Lett ; 9(10): 1039-1044, 2018 Oct 11.
Article in En | MEDLINE | ID: mdl-30344914
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies Language: En Journal: ACS Med Chem Lett Year: 2018 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies Language: En Journal: ACS Med Chem Lett Year: 2018 Type: Article Affiliation country: United States