Low doses of dasiglucagon consistently increase plasma glucose levels from hypoglycaemia and euglycaemia in people with type 1 diabetes mellitus.

Hövelmann, Ulrike; Olsen, Minna Braendholt; Mouritzen, Ulrik; Lamers, Daniela; Kronshage, Birgit; Heise, Tim

Hövelmann, Ulrike; Olsen, Minna Braendholt; Mouritzen, Ulrik; Lamers, Daniela; Kronshage, Birgit; Heise, Tim.

Affiliation

Hövelmann U; Profil, Neuss, Germany.
Olsen MB; Zealand Pharma A/S, Glostrup, Denmark.
Mouritzen U; Zealand Pharma A/S, Glostrup, Denmark.
Lamers D; Profil, Neuss, Germany.
Kronshage B; Profil, Neuss, Germany.
Heise T; Profil, Neuss, Germany.

Diabetes Obes Metab ; 21(3): 601-610, 2019 03.

Article in En | MEDLINE | ID: mdl-30350477

Subject(s)

Blood Glucose/drug effects; Diabetes Mellitus, Type 1/drug therapy; Diabetes Mellitus, Type 1/metabolism; Glucagon/administration & dosage; Glucagon/pharmacokinetics; Hypoglycemia/drug therapy; Adolescent; Adult; Area Under Curve; Blood Glucose/metabolism; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Glucagon/adverse effects; Glucagon/analogs & derivatives; Humans; Hypoglycemia/chemically induced; Hypoglycemia/metabolism; Injections, Subcutaneous; Insulin/administration & dosage; Insulin/adverse effects; Insulin Infusion Systems; Male; Middle Aged; Pancreas, Artificial; Young Adult

Key words

glucagon; hypoglycaemia; pharmacodynamics; pharmacokinetics; type 1 diabetes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Glucose / Glucagon / Diabetes Mellitus, Type 1 / Hypoglycemia Type of study: Clinical_trials / Prognostic_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: Diabetes Obes Metab Journal subject: ENDOCRINOLOGIA / METABOLISMO Year: 2019 Type: Article Affiliation country: Germany

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