Interferon-&#945; Up-Regulates the Expression of PD-L1 Molecules on Immune Cells Through STAT3 and p38 Signaling.

Bazhin, Alexandr V; von Ahn, Katharina; Fritz, Jasmin; Werner, Jens; Karakhanova, Svetlana

Interferon-α Up-Regulates the Expression of PD-L1 Molecules on Immune Cells Through STAT3 and p38 Signaling.

Bazhin, Alexandr V; von Ahn, Katharina; Fritz, Jasmin; Werner, Jens; Karakhanova, Svetlana.

Affiliation

Bazhin AV; Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany.
von Ahn K; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.
Fritz J; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Werner J; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Karakhanova S; Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany.

Front Immunol ; 9: 2129, 2018.

Article in En | MEDLINE | ID: mdl-30356906

Subject(s)

B7-H1 Antigen/metabolism; Dendritic Cells/immunology; Interferon-alpha/metabolism; MAP Kinase Signaling System/immunology; Animals; B7-H1 Antigen/immunology; Blood Buffy Coat/cytology; Cells, Cultured; Coculture Techniques; Dendritic Cells/metabolism; Healthy Volunteers; Humans; Interferon-alpha/immunology; MAP Kinase Signaling System/drug effects; Mice; Mice, Inbred C57BL; Primary Cell Culture; STAT3 Transcription Factor/antagonists & inhibitors; STAT3 Transcription Factor/metabolism; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; Up-Regulation/immunology; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases/metabolism

Key words

IFNα; PD-L1 (B7-H1); STAT3 signaling; cancer immunotherapy; dendritic cell; immunosuppression

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / Interferon-alpha / MAP Kinase Signaling System / B7-H1 Antigen Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Front Immunol Year: 2018 Type: Article Affiliation country: Germany

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