Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions.

Huang, Sun; Chen, Lina; Bladen, Chris; Stys, Peter K; Zamponi, Gerald W

Huang, Sun; Chen, Lina; Bladen, Chris; Stys, Peter K; Zamponi, Gerald W.

Affiliation

Huang S; Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada.
Chen L; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Bladen C; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada.
Stys PK; Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada.
Zamponi GW; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.

Mol Brain ; 11(1): 62, 2018 10 25.

Article in En | MEDLINE | ID: mdl-30359282

Subject(s)

Copper/pharmacology; Prion Proteins/metabolism; Receptors, AMPA/metabolism; Receptors, N-Methyl-D-Aspartate/metabolism; Animals; Cells, Cultured; Humans; Ions; Mice, Inbred C57BL; Mice, Transgenic; Neurons/metabolism

Key words

AMPA receptor; CNS disorders; Cellular prion protein; Copper; Hippocampal neurons; Knock-in mice; NMDA receptor; Whole-cell patch clamp

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, N-Methyl-D-Aspartate / Receptors, AMPA / Copper / Prion Proteins Limits: Animals / Humans Language: En Journal: Mol Brain Journal subject: BIOLOGIA MOLECULAR / CEREBRO Year: 2018 Type: Article Affiliation country: Canada

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