Cathepsin B-Mediated NLRP3 Inflammasome Formation and Activation in Angiotensin II -Induced Hypertensive Mice: Role of Macrophage Digestion Dysfunction.

Lian, Dawei; Lai, Jieqing; Wu, Yanjiao; Wang, Lei; Chen, Yongjun; Zhang, Yang; Boini, Krishna M; Huang, Yi; Chen, Yang

Lian, Dawei; Lai, Jieqing; Wu, Yanjiao; Wang, Lei; Chen, Yongjun; Zhang, Yang; Boini, Krishna M; Huang, Yi; Chen, Yang.

Affiliation

Lian D; School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, China.
Lai J; School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, China.
Wu Y; School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, China.
Wang L; School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, China.
Chen Y; South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou, China.
Zhang Y; Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas, USA.
Boini KM; Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas, USA.
Huang Y; Medical Center of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Chen Y; School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Chinaychen8@gzucm.edu.cn.

Cell Physiol Biochem ; 50(4): 1585-1600, 2018.

Article in En | MEDLINE | ID: mdl-30359991

Subject(s)

Angiotensin II/pharmacology; Cathepsin B/metabolism; Inflammasomes/metabolism; Macrophages/drug effects; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Animals; Cathepsin B/antagonists & inhibitors; Cell Line; Cell Membrane Permeability/drug effects; Chalcones/pharmacology; Escherichia coli/physiology; Hypertension/metabolism; Hypertension/pathology; Losartan/pharmacology; Lysosomes/metabolism; Macrophages/cytology; Macrophages/metabolism; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors; NLR Family, Pyrin Domain-Containing 3 Protein/genetics; Nitric Oxide/metabolism; Phagocytosis/drug effects; RNA Interference; RNA, Small Interfering/metabolism

Key words

Angiotensin II; Cathepsin B; Hypertension; Macrophage digestion; NLRP3 inflammasome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Angiotensin II / Cathepsin B / Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein / Macrophages Limits: Animals Language: En Journal: Cell Physiol Biochem Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2018 Type: Article Affiliation country: China

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