Rs217727 polymorphism in H19 promotes cell apoptosis by regulating the expressions of H19 and the activation of its downstream signaling pathway.

Ge, Lili; Wang, Qinglei; Hu, Shengnan; Yang, Xiaoang

Ge, Lili; Wang, Qinglei; Hu, Shengnan; Yang, Xiaoang.

Affiliation

Ge L; Henan Provincial Key Labratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University (Henan Children's Hospital, Zhengzhou Children's Hospital), Zhengzhou, Henan, China.
Wang Q; Department of Pediatric Orthopedics, Zhengzhou Orthopedic Hospital, Zhengzhou, Henan, China.
Hu S; Department of Liver Disease, Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Yang X; Department of Liver Disease, Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.

J Cell Physiol ; 234(5): 7279-7291, 2019 05.

Article in En | MEDLINE | ID: mdl-30362559

Subject(s)

Apoptosis; Carcinoma, Hepatocellular/metabolism; Liver Neoplasms/metabolism; Polymorphism, Single Nucleotide; RNA, Long Noncoding/metabolism; 3' Untranslated Regions; Binding Sites; Carcinoma, Hepatocellular/genetics; Carcinoma, Hepatocellular/mortality; Carcinoma, Hepatocellular/pathology; Caspase 3/metabolism; Caspase 8/metabolism; Cell Proliferation; Fas-Associated Death Domain Protein/metabolism; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms/genetics; Liver Neoplasms/mortality; Liver Neoplasms/pathology; Male; RNA, Long Noncoding/genetics; Signal Transduction

Key words

FADD; H19; caspase-3; caspase-8; hepatoblastoma; rs217727

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Carcinoma, Hepatocellular / Polymorphism, Single Nucleotide / RNA, Long Noncoding / Liver Neoplasms Limits: Female / Humans / Male Language: En Journal: J Cell Physiol Year: 2019 Type: Article Affiliation country: China

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