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Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Laursen, Nick S; Friesen, Robert H E; Zhu, Xueyong; Jongeneelen, Mandy; Blokland, Sven; Vermond, Jan; van Eijgen, Alida; Tang, Chan; van Diepen, Harry; Obmolova, Galina; van der Neut Kolfschoten, Marijn; Zuijdgeest, David; Straetemans, Roel; Hoffman, Ryan M B; Nieusma, Travis; Pallesen, Jesper; Turner, Hannah L; Bernard, Steffen M; Ward, Andrew B; Luo, Jinquan; Poon, Leo L M; Tretiakova, Anna P; Wilson, James M; Limberis, Maria P; Vogels, Ronald; Brandenburg, Boerries; Kolkman, Joost A; Wilson, Ian A.
Affiliation
  • Laursen NS; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Friesen RHE; Janssen Research and Development, Spring House, PA 19002, USA.
  • Zhu X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Jongeneelen M; Janssen Vaccines and Prevention, Archimedesweg 4-6, 2333 CN, Leiden, Netherlands.
  • Blokland S; Janssen Vaccines and Prevention, Archimedesweg 4-6, 2333 CN, Leiden, Netherlands.
  • Vermond J; Janssen Prevention Center, Archimedesweg 6, 2333 CN, Leiden, Netherlands.
  • van Eijgen A; Janssen Prevention Center, Archimedesweg 6, 2333 CN, Leiden, Netherlands.
  • Tang C; Janssen Vaccines and Prevention, Archimedesweg 4-6, 2333 CN, Leiden, Netherlands.
  • van Diepen H; Janssen Prevention Center, Archimedesweg 6, 2333 CN, Leiden, Netherlands.
  • Obmolova G; Janssen Research and Development, Spring House, PA 19002, USA.
  • van der Neut Kolfschoten M; Janssen Vaccines and Prevention, Archimedesweg 4-6, 2333 CN, Leiden, Netherlands.
  • Zuijdgeest D; Janssen Vaccines and Prevention, Archimedesweg 4-6, 2333 CN, Leiden, Netherlands.
  • Straetemans R; Quantitative Sciences, Janssen Pharmaceutical Companies of Johnson and Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Hoffman RMB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Nieusma T; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Pallesen J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Bernard SM; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Luo J; Janssen Research and Development, Spring House, PA 19002, USA.
  • Poon LLM; Center of Influenza Research and School of Public Health, The University of Hong Kong, Hong Kong SAR, China.
  • Tretiakova AP; Gene Therapy Program, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Wilson JM; Gene Therapy Program, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Limberis MP; Gene Therapy Program, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Vogels R; Janssen Vaccines and Prevention, Archimedesweg 4-6, 2333 CN, Leiden, Netherlands.
  • Brandenburg B; Janssen Vaccines and Prevention, Archimedesweg 4-6, 2333 CN, Leiden, Netherlands.
  • Kolkman JA; Janssen Infectious Diseases, Turnhoutseweg 30, 2340, Beerse, Belgium. wilson@scripps.edu jkolkman@its.jnj.com.
  • Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. wilson@scripps.edu jkolkman@its.jnj.com.
Science ; 362(6414): 598-602, 2018 11 02.
Article in En | MEDLINE | ID: mdl-30385580
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Influenza A virus / Influenza B virus / Camelids, New World / Influenza Vaccines / Orthomyxoviridae Infections / Hemagglutinin Glycoproteins, Influenza Virus / Antibodies, Neutralizing / Antibodies, Viral Limits: Animals Language: En Journal: Science Year: 2018 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Influenza A virus / Influenza B virus / Camelids, New World / Influenza Vaccines / Orthomyxoviridae Infections / Hemagglutinin Glycoproteins, Influenza Virus / Antibodies, Neutralizing / Antibodies, Viral Limits: Animals Language: En Journal: Science Year: 2018 Type: Article Affiliation country: United States