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Design of amidobenzimidazole STING receptor agonists with systemic activity.
Ramanjulu, Joshi M; Pesiridis, G Scott; Yang, Jingsong; Concha, Nestor; Singhaus, Robert; Zhang, Shu-Yun; Tran, Jean-Luc; Moore, Patrick; Lehmann, Stephanie; Eberl, H Christian; Muelbaier, Marcel; Schneck, Jessica L; Clemens, Jim; Adam, Michael; Mehlmann, John; Romano, Joseph; Morales, Angel; Kang, James; Leister, Lara; Graybill, Todd L; Charnley, Adam K; Ye, Guosen; Nevins, Neysa; Behnia, Kamelia; Wolf, Amaya I; Kasparcova, Viera; Nurse, Kelvin; Wang, Liping; Puhl, Ana C; Li, Yue; Klein, Michael; Hopson, Christopher B; Guss, Jeffrey; Bantscheff, Marcus; Bergamini, Giovanna; Reilly, Michael A; Lian, Yiqian; Duffy, Kevin J; Adams, Jerry; Foley, Kevin P; Gough, Peter J; Marquis, Robert W; Smothers, James; Hoos, Axel; Bertin, John.
Affiliation
  • Ramanjulu JM; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA. joshi.m.ramanjulu@gsk.com.
  • Pesiridis GS; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Yang J; Immuno-Oncology & Combinations DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Concha N; Platform Technology & Science, GlaxoSmithKline, Collegeville, PA, USA.
  • Singhaus R; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Zhang SY; Immuno-Oncology & Combinations DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Tran JL; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Moore P; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Lehmann S; Cellzome, GlaxoSmithKline R&D, Heidelberg, Germany.
  • Eberl HC; Cellzome, GlaxoSmithKline R&D, Heidelberg, Germany.
  • Muelbaier M; Cellzome, GlaxoSmithKline R&D, Heidelberg, Germany.
  • Schneck JL; Platform Technology & Science, GlaxoSmithKline, Collegeville, PA, USA.
  • Clemens J; Platform Technology & Science, GlaxoSmithKline, Collegeville, PA, USA.
  • Adam M; Immuno-Oncology & Combinations DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Mehlmann J; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Romano J; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Morales A; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Kang J; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Leister L; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Graybill TL; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Charnley AK; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Ye G; Platform Technology & Science, GlaxoSmithKline, Collegeville, PA, USA.
  • Nevins N; Platform Technology & Science, GlaxoSmithKline, Collegeville, PA, USA.
  • Behnia K; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Wolf AI; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Kasparcova V; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Nurse K; Platform Technology & Science, GlaxoSmithKline, Collegeville, PA, USA.
  • Wang L; Platform Technology & Science, GlaxoSmithKline, Collegeville, PA, USA.
  • Puhl AC; Platform Technology & Science, GlaxoSmithKline, Collegeville, PA, USA.
  • Li Y; Platform Technology & Science, GlaxoSmithKline, Collegeville, PA, USA.
  • Klein M; Platform Technology & Science, GlaxoSmithKline, Collegeville, PA, USA.
  • Hopson CB; Immuno-Oncology & Combinations DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Guss J; Platform Technology & Science, GlaxoSmithKline, Collegeville, PA, USA.
  • Bantscheff M; Cellzome, GlaxoSmithKline R&D, Heidelberg, Germany.
  • Bergamini G; Cellzome, GlaxoSmithKline R&D, Heidelberg, Germany.
  • Reilly MA; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Lian Y; Immuno-Oncology & Combinations DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Duffy KJ; Immuno-Oncology & Combinations DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Adams J; Immuno-Oncology & Combinations DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Foley KP; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Gough PJ; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Marquis RW; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Smothers J; Immuno-Oncology & Combinations DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Hoos A; Immuno-Oncology & Combinations DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Bertin J; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
Nature ; 564(7736): 439-443, 2018 12.
Article in En | MEDLINE | ID: mdl-30405246
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Drug Design / Colonic Neoplasms / Membrane Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2018 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Drug Design / Colonic Neoplasms / Membrane Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2018 Type: Article Affiliation country: United States