Genetically Encoding Albumin Binding into Chemotherapeutic-loaded Polypeptide Nanoparticles Enhances Their Antitumor Efficacy.

Yousefpour, Parisa; McDaniel, Jonathan R; Prasad, Varun; Ahn, Lucie; Li, Xinghai; Subrahmanyan, Rishi; Weitzhandler, Isaac; Suter, Steven; Chilkoti, Ashutosh

Yousefpour, Parisa; McDaniel, Jonathan R; Prasad, Varun; Ahn, Lucie; Li, Xinghai; Subrahmanyan, Rishi; Weitzhandler, Isaac; Suter, Steven; Chilkoti, Ashutosh.

Affiliation

Suter S; Department of Clinical Sciences , North Carolina State University , Raleigh , North Carolina 27607 , United States.

Nano Lett ; 18(12): 7784-7793, 2018 12 12.

Article in En | MEDLINE | ID: mdl-30461287

Subject(s)

Albumins/metabolism; Antibiotics, Antineoplastic/administration & dosage; Doxorubicin/administration & dosage; Drug Carriers/metabolism; Nanoparticles/metabolism; Peptides/metabolism; Animals; Antibiotics, Antineoplastic/pharmacokinetics; Binding Sites; Cell Line, Tumor; Dogs; Doxorubicin/pharmacokinetics; Drug Carriers/chemistry; Humans; Mice; Micelles; Nanoparticles/chemistry; Neoplasms/drug therapy; Neoplasms/metabolism; Peptides/chemistry; Protein Binding; Protein Domains; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/metabolism

Key words

Micelles; cancer; canine model; drug delivery; elastin like polypeptide; endogenous albumin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Drug Carriers / Doxorubicin / Albumins / Nanoparticles / Antibiotics, Antineoplastic Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nano Lett Year: 2018 Type: Article

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