Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin, adipose tissue and liver.
Biochem Biophys Res Commun
; 508(1): 87-91, 2019 01 01.
Article
in En
| MEDLINE
| ID: mdl-30470572
ABSTRACT
Stearoyl-CoA desaturase 1 (SCD1), a lipogenic enzyme that adds a double bond at the delta 9 position of stearate (C18 0) and palmitate (C16 0), has been proven to be important in the development of obesity. Mice with skin-specific deficiency of SCD1 (SKO) display increased whole-body energy expenditure, which is protective against adiposity from a high-fat diet because it improves glucose clearance, insulin sensitivity, and hepatic steatosis. Of note, these mice also display elevated levels of the "pro-inflammatory" plasma interleukin-6 (IL-6). In whole skin of SKO mice, IL-6 mRNA levels are increased, and protein expression is evident in hair follicle cells and in keratinocytes. Recently, the well-known role of IL-6 in causing white adipose tissue lipolysis has been linked to indirectly activating the gluconeogenic enzyme pyruvate carboxylase 1 in the liver, thereby increasing hepatic glucose production. In this study, we suggest that skin-derived IL-6 leads to white adipose tissue lipolysis, which contributes to the lean phenotype of SKO mice without the incidence of meta-inflammation that is associated with IL-6 signaling.
Key words
Adipose; Diabetes; Fat; Gluconeogenesis; Glucose; IL6; Inflammation; Lipids; Liver; Metabolism; Obesity; SCD1; Skin; Steatosis
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin
/
Stearoyl-CoA Desaturase
/
Interleukin-6
Limits:
Animals
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2019
Type:
Article
Affiliation country:
United States