Blocking the REDD1/TXNIP axis ameliorates LPS-induced vascular endothelial cell injury through repressing oxidative stress and apoptosis.

Hou, Xuhui; Yang, Songbai; Yin, Jian

Hou, Xuhui; Yang, Songbai; Yin, Jian.

Affiliation

Hou X; Department of Vascular Surgery, China-Japan Union Hospital, Jilin University , Changchun , People's Republic of China.
Yang S; Department of Vascular Surgery, China-Japan Union Hospital, Jilin University , Changchun , People's Republic of China.
Yin J; Department of Vascular Surgery, China-Japan Union Hospital, Jilin University , Changchun , People's Republic of China.

Am J Physiol Cell Physiol ; 316(1): C104-C110, 2019 01 01.

Article in En | MEDLINE | ID: mdl-30485138

Subject(s)

Apoptosis/physiology; Carrier Proteins/metabolism; Endothelium, Vascular/metabolism; Human Umbilical Vein Endothelial Cells/metabolism; Oxidative Stress/physiology; Transcription Factors/metabolism; Apoptosis/drug effects; Carrier Proteins/antagonists & inhibitors; Endothelium, Vascular/drug effects; Gene Knockdown Techniques/methods; Human Umbilical Vein Endothelial Cells/drug effects; Humans; Lipopolysaccharides/toxicity; Oxidative Stress/drug effects; RNA, Small Interfering/pharmacology; Transcription Factors/antagonists & inhibitors

Key words

REDD1; apoptosis; endothelial injury; human umbilical vein endothelial cells; oxidative stress

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Endothelium, Vascular / Carrier Proteins / Apoptosis / Oxidative Stress / Human Umbilical Vein Endothelial Cells Limits: Humans Language: En Journal: Am J Physiol Cell Physiol Journal subject: FISIOLOGIA Year: 2019 Type: Article

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