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Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing.
Lo Sardo, Valentina; Chubukov, Pavel; Ferguson, William; Kumar, Aditya; Teng, Evan L; Duran, Michael; Zhang, Lei; Cost, Gregory; Engler, Adam J; Urnov, Fyodor; Topol, Eric J; Torkamani, Ali; Baldwin, Kristin K.
Affiliation
  • Lo Sardo V; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Chubukov P; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Ferguson W; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Kumar A; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093-0412, USA.
  • Teng EL; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093-0412, USA.
  • Duran M; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Zhang L; Sangamo BioSciences, Inc., Richmond, CA 94804-3517, USA.
  • Cost G; Sangamo BioSciences, Inc., Richmond, CA 94804-3517, USA.
  • Engler AJ; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093-0412, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA.
  • Urnov F; Sangamo BioSciences, Inc., Richmond, CA 94804-3517, USA.
  • Topol EJ; Scripps Research Translational Institute, The Scripps Research Institute, La Jolla, CA, 92037, USA; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, CA.
  • Torkamani A; Scripps Research Translational Institute, The Scripps Research Institute, La Jolla, CA, 92037, USA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Baldwin KK; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: kbaldwin@scripps.edu.
Cell ; 175(7): 1796-1810.e20, 2018 12 13.
Article in En | MEDLINE | ID: mdl-30528432
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromosomes, Human, Pair 9 / Coronary Artery Disease / Haplotypes / Polymorphism, Single Nucleotide / Induced Pluripotent Stem Cells / Gene Editing Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Cell Year: 2018 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromosomes, Human, Pair 9 / Coronary Artery Disease / Haplotypes / Polymorphism, Single Nucleotide / Induced Pluripotent Stem Cells / Gene Editing Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Cell Year: 2018 Type: Article Affiliation country: United States