Up-regulated ferritin in periodontitis promotes inflammatory cytokine expression in human periodontal ligament cells through transferrin receptor via ERK/P38 MAPK pathways.

Huang, Wenxue; Zhan, Yalin; Zheng, Yunfei; Han, Ye; Hu, Wenjie; Hou, Jianxia

Huang, Wenxue; Zhan, Yalin; Zheng, Yunfei; Han, Ye; Hu, Wenjie; Hou, Jianxia.

Affiliation

Huang W; Department of Periodontology, Peking University School and Hospital of Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing 100081, P.R. China.
Zhan Y; National Clinical Research Center for Oral Diseases, Peking University School and Hospital of Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing 100081, P.R. China.
Zheng Y; National Engineering Laboratory for Digital and Material Technology of Stomatology, Peking University School and Hospital of Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing 100081, P.R. China.
Han Y; Beijing Key Laboratory of Digital Stomatology, Peking University School and Hospital of Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing 100081, P.R. China.
Hu W; National Clinical Research Center for Oral Diseases, Peking University School and Hospital of Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing 100081, P.R. China.
Hou J; National Engineering Laboratory for Digital and Material Technology of Stomatology, Peking University School and Hospital of Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing 100081, P.R. China.

Clin Sci (Lond) ; 133(1): 135-148, 2019 01 15.

Article in En | MEDLINE | ID: mdl-30552136

Subject(s)

Antigens, CD/metabolism; Apoferritins/metabolism; Cytokines/metabolism; Extracellular Signal-Regulated MAP Kinases/metabolism; Ferritins/metabolism; Inflammation Mediators/metabolism; Periodontal Ligament/enzymology; Periodontitis/enzymology; Receptors, Transferrin/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism; Animals; Antigens, CD/genetics; Apoferritins/genetics; Case-Control Studies; Cells, Cultured; Disease Models, Animal; Ferritins/genetics; Humans; Interleukin-6/metabolism; Interleukin-8/metabolism; Male; Mice, Inbred C57BL; Oxidoreductases; Periodontal Ligament/pathology; Periodontitis/genetics; Periodontitis/pathology; Receptors, Transferrin/genetics; Signal Transduction; Tumor Necrosis Factor-alpha/metabolism; Up-Regulation

Key words

Ferritin; Inflammation; Periodontal ligament; Periodontitis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoferritins / Periodontal Ligament / Periodontitis / Receptors, Transferrin / Antigens, CD / Cytokines / Inflammation Mediators / Extracellular Signal-Regulated MAP Kinases / P38 Mitogen-Activated Protein Kinases / Ferritins Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: Clin Sci (Lond) Year: 2019 Type: Article

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