Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6.

Uehara, Shotaro; Murayama, Norie; Yamazaki, Hiroshi; Suemizu, Hiroshi

Uehara, Shotaro; Murayama, Norie; Yamazaki, Hiroshi; Suemizu, Hiroshi.

Affiliation

Uehara S; a Central Institute for Experimental Animals , Kawasaki , Japan.
Murayama N; b Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Machida , Japan.
Yamazaki H; b Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Machida , Japan.
Suemizu H; a Central Institute for Experimental Animals , Kawasaki , Japan.

Xenobiotica ; 49(11): 1323-1331, 2019 Nov.

Article in En | MEDLINE | ID: mdl-30596462

Subject(s)

Aryl Hydrocarbon Hydroxylases/metabolism; Cytochrome P-450 CYP2D6/metabolism; Microsomes, Liver/metabolism; Propafenone/pharmacokinetics; Adult; Aged; Animals; Anti-Arrhythmia Agents/chemistry; Anti-Arrhythmia Agents/metabolism; Anti-Arrhythmia Agents/pharmacokinetics; Aryl Hydrocarbon Hydroxylases/chemistry; Callithrix; Cytochrome P-450 CYP2D6/chemistry; Cytochrome P-450 Enzyme Inhibitors/pharmacology; Dogs; Female; Humans; Hydroxylation; Macaca fascicularis; Male; Mice, Inbred Strains; Microsomes, Liver/drug effects; Middle Aged; Propafenone/chemistry; Propafenone/metabolism; Rats, Sprague-Dawley; Species Specificity; Swine; Swine, Miniature

Key words

CYP2D2; CYP2D6; Cytochrome P450; propafenone

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Propafenone / Microsomes, Liver / Aryl Hydrocarbon Hydroxylases / Cytochrome P-450 CYP2D6 Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Xenobiotica Year: 2019 Type: Article Affiliation country: Japan

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