mPGES-1-Mediated Production of PGE<sub>2</sub> and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation.

Maseda, Damian; Banerjee, Amrita; Johnson, Elizabeth M; Washington, Mary Kay; Kim, Hyeyon; Lau, Ken S; Crofford, Leslie J

mPGES-1-Mediated Production of PGE₂ and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation.

Maseda, Damian; Banerjee, Amrita; Johnson, Elizabeth M; Washington, Mary Kay; Kim, Hyeyon; Lau, Ken S; Crofford, Leslie J.

Affiliation

Maseda D; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.
Banerjee A; Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Johnson EM; Department of Cell and Developmental Biology, Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, TN, United States.
Washington MK; Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Kim H; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.
Lau KS; Department of Cell and Developmental Biology, Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, TN, United States.
Crofford LJ; Department of Cell and Developmental Biology, Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, TN, United States.

Front Immunol ; 9: 2954, 2018.

Article in En | MEDLINE | ID: mdl-30619314

Subject(s)

Colitis/immunology; Dinoprostone/immunology; Prostaglandin-E Synthases/immunology; Receptors, Prostaglandin E, EP4 Subtype/immunology; T-Lymphocytes/immunology; Animals; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/metabolism; Colitis/genetics; Colitis/metabolism; Dinoprostone/metabolism; Intestinal Mucosa/immunology; Intestinal Mucosa/metabolism; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Nuclear Receptor Subfamily 1, Group F, Member 3/immunology; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism; Prostaglandin-E Synthases/genetics; Prostaglandin-E Synthases/metabolism; Receptors, Prostaglandin E, EP2 Subtype/genetics; Receptors, Prostaglandin E, EP2 Subtype/immunology; Receptors, Prostaglandin E, EP2 Subtype/metabolism; Receptors, Prostaglandin E, EP4 Subtype/genetics; Receptors, Prostaglandin E, EP4 Subtype/metabolism; T-Lymphocytes/metabolism; T-Lymphocytes, Regulatory/immunology; T-Lymphocytes, Regulatory/metabolism

Key words

IBDinflammatory bowel diseases; PGE2; T cell; Th17 & Tregs cells; Th17 activation; Treg = regulatory T cell; colitis; inflammation immunomodulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Dinoprostone / Colitis / Receptors, Prostaglandin E, EP4 Subtype / Prostaglandin-E Synthases Limits: Animals Language: En Journal: Front Immunol Year: 2018 Type: Article Affiliation country: United States

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