A Transplantable Syngeneic Allograft Mouse Model for Nongestational Choriocarcinoma of the Ovary.
Vet Pathol
; 56(3): 399-403, 2019 05.
Article
in En
| MEDLINE
| ID: mdl-30636537
ABSTRACT
Nongestational choriocarcinoma is a rare malignancy in humans with poor prognosis. Naturally occurring choriocarcinoma is also rare in laboratory mice, and no genetic mouse model accurately recapitulates the features of this cancer. Here we report development of a genetically engineered mouse (GEM) model with alterations in Brca2, Trp53, and RB that develops ovarian tumors. Most of the ovarian tumors displayed histological characteristics of nongestational choriocarcinoma of the ovary (NGCO) (47%) with abundant syncytiotrophoblasts and cytotrophoblasts, positive immunolabeling for human chorionic gonadotropin, and positive periodic acid-Schiff reaction. The rest of the ovarian tumors were serous epithelial ovarian carcinoma (SEOC) (26%) or mixed tumors consisting of NGCO and SEOC (26%). We further established syngeneic orthotopic mouse models for NGCO by in vivo passaging of GEM tumors. These metastatic models provide a platform for evaluating new treatment strategies in preclinical studies aimed at improving outcomes in choriocarcinoma patients.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Choriocarcinoma, Non-gestational
/
Neoplasm Transplantation
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Vet Pathol
Year:
2019
Type:
Article
Affiliation country:
United States