BUD13 Promotes a Type I Interferon Response by Countering Intron Retention in Irf7.

Frankiw, Luke; Majumdar, Devdoot; Burns, Christian; Vlach, Logan; Moradian, Annie; Sweredoski, Michael J; Baltimore, David

Frankiw, Luke; Majumdar, Devdoot; Burns, Christian; Vlach, Logan; Moradian, Annie; Sweredoski, Michael J; Baltimore, David.

Affiliation

Frankiw L; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Majumdar D; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Burns C; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Vlach L; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Moradian A; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Sweredoski MJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Baltimore D; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: baltimo@caltech.edu.

Mol Cell ; 73(4): 803-814.e6, 2019 02 21.

Article in En | MEDLINE | ID: mdl-30639243

Subject(s)

Interferon Regulatory Factor-7/metabolism; Interferon Type I/metabolism; Introns; Macrophages/metabolism; RNA-Binding Proteins/metabolism; Vesicular Stomatitis/metabolism; Vesicular stomatitis Indiana virus/pathogenicity; Animals; Binding Sites; Chlorocebus aethiops; GC Rich Sequence; HEK293 Cells; Host-Pathogen Interactions; Humans; Interferon Regulatory Factor-7/genetics; Interferon Type I/immunology; Macrophages/immunology; Macrophages/virology; Mice, Inbred C57BL; Protein Binding; RNA Splice Sites; RNA Splicing; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA-Binding Proteins/genetics; Vero Cells; Vesicular Stomatitis/genetics; Vesicular Stomatitis/immunology; Vesicular Stomatitis/virology; Vesicular stomatitis Indiana virus/immunology

Key words

Bud13; Irf7; RES complex; inflammation; intron retention; spliceosome; type I interferons

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Introns / Interferon Type I / RNA-Binding Proteins / Vesicular stomatitis Indiana virus / Interferon Regulatory Factor-7 / Vesicular Stomatitis / Macrophages Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2019 Type: Article Affiliation country: United States

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