Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma.

Wong, Kim; van der Weyden, Louise; Schott, Courtney R; Foote, Alastair; Constantino-Casas, Fernando; Smith, Sionagh; Dobson, Jane M; Murchison, Elizabeth P; Wu, Hong; Yeh, Iwei; Fullen, Douglas R; Joseph, Nancy; Bastian, Boris C; Patel, Rajiv M; Martincorena, Inigo; Robles-Espinoza, Carla Daniela; Iyer, Vivek; Kuijjer, Marieke L; Arends, Mark J; Brenn, Thomas; Harms, Paul W; Wood, Geoffrey A; Adams, David J

Wong, Kim; van der Weyden, Louise; Schott, Courtney R; Foote, Alastair; Constantino-Casas, Fernando; Smith, Sionagh; Dobson, Jane M; Murchison, Elizabeth P; Wu, Hong; Yeh, Iwei; Fullen, Douglas R; Joseph, Nancy; Bastian, Boris C; Patel, Rajiv M; Martincorena, Inigo; Robles-Espinoza, Carla Daniela; Iyer, Vivek; Kuijjer, Marieke L; Arends, Mark J; Brenn, Thomas; Harms, Paul W; Wood, Geoffrey A; Adams, David J.

Affiliation

Wong K; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
van der Weyden L; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Schott CR; Department of Pathobiology, University of Guelph, 50 Stone Road E., Guelph, ON, N1G 2W1, Canada.
Foote A; Rossdales Equine Hospital and Diagnostic Centre, High Street, Newmarket, Suffolk, CB8 8JS, UK.
Constantino-Casas F; Department of Veterinary Medicine, Cambridge Veterinary School, University of Cambridge, Cambridge, CB3 0ES, UK.
Smith S; The Royal (Dick) School of Veterinary Studies and The Roslin Institute, Easter Bush Campus, Midlothian, EH25 9RG, UK.
Dobson JM; Department of Veterinary Medicine, Cambridge Veterinary School, University of Cambridge, Cambridge, CB3 0ES, UK.
Murchison EP; Department of Veterinary Medicine, Cambridge Veterinary School, University of Cambridge, Cambridge, CB3 0ES, UK.
Wu H; Departments of Dermatology and Pathology, University of California, San Francisco, CA, 94143, USA.
Yeh I; Departments of Dermatology and Pathology, University of California, San Francisco, CA, 94143, USA.
Fullen DR; Departments of Pathology and Dermatology, University of Michigan Medical School, 3261 Medical Science I, 1301 Catherine, Ann Arbor, MI, 48109-5602, USA.
Joseph N; Departments of Dermatology and Pathology, University of California, San Francisco, CA, 94143, USA.
Bastian BC; Departments of Dermatology and Pathology, University of California, San Francisco, CA, 94143, USA.
Patel RM; Departments of Pathology and Dermatology, University of Michigan Medical School, 3261 Medical Science I, 1301 Catherine, Ann Arbor, MI, 48109-5602, USA.
Martincorena I; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Robles-Espinoza CD; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Iyer V; Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Campus Juriquilla, Blvd Juriquilla 3001, Santiago de Querétaro, 76230, Mexico.
Kuijjer ML; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Arends MJ; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, 02215, USA.
Brenn T; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Harms PW; Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, Faculty of Medicine, University of Oslo, 0349, Oslo, Norway.
Wood GA; University of Edinburgh, Division of Pathology, Centre for Comparative Pathology, Cancer Research UK Edinburgh Centre, Institute of Genetics & Molecular Medicine, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XR, UK.
Adams DJ; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

Nat Commun ; 10(1): 353, 2019 01 21.

Article in En | MEDLINE | ID: mdl-30664638

Subject(s)

Carcinogenesis/genetics; Gene Expression Regulation, Neoplastic; Germ-Line Mutation; Melanoma/genetics; Mouth Neoplasms/genetics; Neoplasm Proteins/genetics; Skin Neoplasms/genetics; Animals; BRCA1 Protein/genetics; BRCA1 Protein/metabolism; BRCA2 Protein/genetics; BRCA2 Protein/metabolism; Cadherins/genetics; Cadherins/metabolism; Carcinogenesis/metabolism; Carcinogenesis/pathology; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; DNA Copy Number Variations; Dogs; GTP Phosphohydrolases/genetics; GTP Phosphohydrolases/metabolism; Horses; Humans; Melanoma/metabolism; Melanoma/pathology; Membrane Proteins/genetics; Membrane Proteins/metabolism; Microtubule-Associated Proteins/genetics; Microtubule-Associated Proteins/metabolism; Mouth Neoplasms/metabolism; Mouth Neoplasms/pathology; Mucous Membrane/metabolism; Mucous Membrane/pathology; Neoplasm Proteins/metabolism; Neoplasm Recurrence, Local; PTEN Phosphohydrolase/genetics; PTEN Phosphohydrolase/metabolism; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins c-mdm2/genetics; Proto-Oncogene Proteins c-mdm2/metabolism; Receptor-Like Protein Tyrosine Phosphatases, Class 3/genetics; Receptor-Like Protein Tyrosine Phosphatases, Class 3/metabolism; Skin Neoplasms/metabolism; Skin Neoplasms/pathology; Species Specificity; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Mouth Neoplasms / Gene Expression Regulation, Neoplastic / Germ-Line Mutation / Carcinogenesis / Melanoma / Neoplasm Proteins Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Type: Article Affiliation country: United kingdom

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