Phosphoglycolate phosphatase is a metabolic proofreading enzyme essential for cellular function in <i>Plasmodium berghei</i>.

Kempaiah Nagappa, Lakshmeesha; Satha, Pardhasaradhi; Govindaraju, Thimmaiah; Balaram, Hemalatha

Phosphoglycolate phosphatase is a metabolic proofreading enzyme essential for cellular function in Plasmodium berghei.

Kempaiah Nagappa, Lakshmeesha; Satha, Pardhasaradhi; Govindaraju, Thimmaiah; Balaram, Hemalatha.

Affiliation

Kempaiah Nagappa L; From the Molecular Biology and Genetics Unit and.
Satha P; Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru, Karnataka 560064, India.
Govindaraju T; Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru, Karnataka 560064, India.
Balaram H; From the Molecular Biology and Genetics Unit and hb@jncasr.ac.in.

J Biol Chem ; 294(13): 4997-5007, 2019 03 29.

Article in En | MEDLINE | ID: mdl-30700551

Subject(s)

Malaria/parasitology; Phosphoric Monoester Hydrolases/metabolism; Plasmodium berghei/metabolism; Protozoan Proteins/metabolism; Animals; Gene Knockout Techniques; Glycolates/metabolism; Glycolysis; Humans; Lactates/metabolism; Mice; Molecular Sequence Data; Phosphoric Monoester Hydrolases/chemistry; Phosphoric Monoester Hydrolases/genetics; Plasmodium berghei/chemistry; Plasmodium berghei/genetics; Protozoan Proteins/chemistry; Protozoan Proteins/genetics; Sequence Alignment; Substrate Specificity

Key words

2-phospho-L-lactate; 2-phosphoglycolate; 4-phosphoerythronate; Plasmodium berghei; gene knockout; glycolysis; malaria; metabolic regulation; phosphatase; phosphoglycolate phosphatase (PGP); protozoan

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium berghei / Protozoan Proteins / Phosphoric Monoester Hydrolases / Malaria Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2019 Type: Article

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