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Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade.
Miller, Brian C; Sen, Debattama R; Al Abosy, Rose; Bi, Kevin; Virkud, Yamini V; LaFleur, Martin W; Yates, Kathleen B; Lako, Ana; Felt, Kristen; Naik, Girish S; Manos, Michael; Gjini, Evisa; Kuchroo, Juhi R; Ishizuka, Jeffrey J; Collier, Jenna L; Griffin, Gabriel K; Maleri, Seth; Comstock, Dawn E; Weiss, Sarah A; Brown, Flavian D; Panda, Arpit; Zimmer, Margaret D; Manguso, Robert T; Hodi, F Stephen; Rodig, Scott J; Sharpe, Arlene H; Haining, W Nicholas.
Affiliation
  • Miller BC; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Sen DR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Al Abosy R; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Bi K; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
  • Virkud YV; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
  • LaFleur MW; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Yates KB; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Lako A; Division of Medical Sciences, Harvard Medical School, Boston, MA, USA.
  • Felt K; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Naik GS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Manos M; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Gjini E; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Kuchroo JR; Division of Pediatric Allergy and Immunology, Massachusetts General Hospital, Boston, MA, USA.
  • Ishizuka JJ; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Collier JL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Griffin GK; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
  • Maleri S; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
  • Comstock DE; Division of Medical Sciences, Harvard Medical School, Boston, MA, USA.
  • Weiss SA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Brown FD; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Panda A; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Zimmer MD; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Manguso RT; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Hodi FS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Rodig SJ; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Sharpe AH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Haining WN; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Nat Immunol ; 20(3): 326-336, 2019 03.
Article in En | MEDLINE | ID: mdl-30778252
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Melanoma, Experimental / Lymphocytes, Tumor-Infiltrating / CD8-Positive T-Lymphocytes / Antibodies, Blocking / Programmed Cell Death 1 Receptor Limits: Animals / Female / Humans Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2019 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Melanoma, Experimental / Lymphocytes, Tumor-Infiltrating / CD8-Positive T-Lymphocytes / Antibodies, Blocking / Programmed Cell Death 1 Receptor Limits: Animals / Female / Humans Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2019 Type: Article Affiliation country: United States