Simplified LC-MS/MS method for quantification of IG-105, a novel tubulin ligand, and its application to the pharmacokinetic study in rats at the anticancer effective dose.

Pang, J; Li, C R; Zhao, R; Nie, T Y; Li, G Q; Lu, X; Hu, X X; Wang, X K; Yang, X Y; You, X F

Pang, J; Li, C R; Zhao, R; Nie, T Y; Li, G Q; Lu, X; Hu, X X; Wang, X K; Yang, X Y; You, X F.

Pharmazie ; 74(2): 79-82, 2019 02 01.

Article in En | MEDLINE | ID: mdl-30782255

Subject(s)

Antineoplastic Agents/blood; Antineoplastic Agents/pharmacokinetics; Carbazoles/blood; Carbazoles/pharmacokinetics; Chromatography, Liquid/methods; Sulfonamides/blood; Sulfonamides/pharmacokinetics; Tandem Mass Spectrometry/methods; Tubulin Modulators; Animals; Dose-Response Relationship, Drug; Female; Male; Rats; Rats, Sprague-Dawley; Tubulin Modulators/blood; Tubulin Modulators/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Carbazoles / Chromatography, Liquid / Tubulin Modulators / Tandem Mass Spectrometry / Antineoplastic Agents Limits: Animals Language: En Journal: Pharmazie Journal subject: FARMACIA Year: 2019 Type: Article

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