Novel Site-Specific Fatty Chain-Modified GLP-1 Receptor Agonist with Potent Antidiabetic Effects.

Zhong, Xia; Chen, Zhu; Chen, Qiong; Zhao, Wei; Chen, Zhi

Zhong, Xia; Chen, Zhu; Chen, Qiong; Zhao, Wei; Chen, Zhi.

Affiliation

Zhong X; College of Life Science and Technology, Jinan University, Guangzhou 510000, China. x_zhong@outlook.com.
Chen Z; Reyoung Biopharmaceuticals Co., Ltd, Suzhou 215000, China. x_zhong@outlook.com.
Chen Q; Reyoung Biopharmaceuticals Co., Ltd, Suzhou 215000, China. Zchen@163.com.
Zhao W; East China University of Science and Technology, Shanghai 200000, China. Zchen@163.com.
Chen Z; Reyoung Biopharmaceuticals Co., Ltd, Suzhou 215000, China. qchen0862@yeah.net.

Molecules ; 24(4)2019 Feb 21.

Article in En | MEDLINE | ID: mdl-30795583

Subject(s)

Glucagon-Like Peptide-1 Receptor/agonists; Glycoconjugates/pharmacology; Hyperglycemia/drug therapy; Hypoglycemic Agents/pharmacology; Insulin-Secreting Cells/drug effects; Obesity/drug therapy; Amino Acid Sequence; Animals; Binding Sites; Cell Line; Diet, High-Fat/adverse effects; Exenatide/genetics; Exenatide/metabolism; Fatty Acids/chemistry; Gene Expression Regulation; Glucagon-Like Peptide-1 Receptor/genetics; Glucagon-Like Peptide-1 Receptor/metabolism; Glucose Tolerance Test; Glycoconjugates/chemistry; Glycoconjugates/metabolism; Hyperglycemia/etiology; Hyperglycemia/genetics; Hyperglycemia/metabolism; Hypoglycemic Agents/chemistry; Hypoglycemic Agents/metabolism; Insulin-Secreting Cells/metabolism; Insulin-Secreting Cells/pathology; Male; Mice; Obesity/etiology; Obesity/genetics; Obesity/metabolism; Peptide Library; Peptides/chemistry; Peptides/metabolism; Peptides/pharmacology; Protein Binding; Rats; Structure-Activity Relationship

Key words

Exendin-4; Glucagon-like peptide-1 receptor; antidiabetic effects; extracellular domain; fatty chain

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glycoconjugates / Insulin-Secreting Cells / Glucagon-Like Peptide-1 Receptor / Hyperglycemia / Hypoglycemic Agents / Obesity Type of study: Etiology_studies Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2019 Type: Article Affiliation country: China

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