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Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis.
Taylor, Mark J; von Geldern, Thomas W; Ford, Louise; Hübner, Marc P; Marsh, Kennan; Johnston, Kelly L; Sjoberg, Hanna T; Specht, Sabine; Pionnier, Nicolas; Tyrer, Hayley E; Clare, Rachel H; Cook, Darren A N; Murphy, Emma; Steven, Andrew; Archer, John; Bloemker, Dominique; Lenz, Franziska; Koschel, Marianne; Ehrens, Alexandra; Metuge, Haelly M; Chunda, Valerinne C; Ndongmo Chounna, Patrick W; Njouendou, Abdel J; Fombad, Fanny F; Carr, Robert; Morton, Howard E; Aljayyoussi, Ghaith; Hoerauf, Achim; Wanji, Samuel; Kempf, Dale J; Turner, Joseph D; Ward, Stephen A.
Affiliation
  • Taylor MJ; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
  • von Geldern TW; Global Pharmaceutical Research and Development, AbbVie, North Chicago, IL, USA.
  • Ford L; Franciscan Institute for World Health, Franciscan University, Steubenville, OH, USA.
  • Hübner MP; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
  • Marsh K; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Johnston KL; Global Pharmaceutical Research and Development, AbbVie, North Chicago, IL, USA.
  • Sjoberg HT; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
  • Specht S; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
  • Pionnier N; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Tyrer HE; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
  • Clare RH; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
  • Cook DAN; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
  • Murphy E; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
  • Steven A; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
  • Archer J; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
  • Bloemker D; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
  • Lenz F; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Koschel M; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Ehrens A; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Metuge HM; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Chunda VC; Research Foundation for Tropical Diseases and the Environment, Buea, Cameroon.
  • Ndongmo Chounna PW; Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.
  • Njouendou AJ; Research Foundation for Tropical Diseases and the Environment, Buea, Cameroon.
  • Fombad FF; Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.
  • Carr R; Research Foundation for Tropical Diseases and the Environment, Buea, Cameroon.
  • Morton HE; Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.
  • Aljayyoussi G; Research Foundation for Tropical Diseases and the Environment, Buea, Cameroon.
  • Hoerauf A; Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.
  • Wanji S; Research Foundation for Tropical Diseases and the Environment, Buea, Cameroon.
  • Kempf DJ; Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.
  • Turner JD; Global Pharmaceutical Research and Development, AbbVie, North Chicago, IL, USA.
  • Ward SA; Global Pharmaceutical Research and Development, AbbVie, North Chicago, IL, USA.
Sci Transl Med ; 11(483)2019 03 13.
Article in En | MEDLINE | ID: mdl-30867321
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Onchocerciasis / Elephantiasis, Filarial / Macrolides / Wolbachia Limits: Animals Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2019 Type: Article Affiliation country: United kingdom
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Onchocerciasis / Elephantiasis, Filarial / Macrolides / Wolbachia Limits: Animals Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2019 Type: Article Affiliation country: United kingdom