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T cell stemness and dysfunction in tumors are triggered by a common mechanism.
Vodnala, Suman Kumar; Eil, Robert; Kishton, Rigel J; Sukumar, Madhusudhanan; Yamamoto, Tori N; Ha, Ngoc-Han; Lee, Ping-Hsien; Shin, MinHwa; Patel, Shashank J; Yu, Zhiya; Palmer, Douglas C; Kruhlak, Michael J; Liu, Xiaojing; Locasale, Jason W; Huang, Jing; Roychoudhuri, Rahul; Finkel, Toren; Klebanoff, Christopher A; Restifo, Nicholas P.
Affiliation
  • Vodnala SK; Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Eil R; Center for Cell-Based Therapy, National Cancer Institute, Bethesda, MD 20892, USA.
  • Kishton RJ; Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Sukumar M; Center for Cell-Based Therapy, National Cancer Institute, Bethesda, MD 20892, USA.
  • Yamamoto TN; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Ha NH; Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Lee PH; Center for Cell-Based Therapy, National Cancer Institute, Bethesda, MD 20892, USA.
  • Shin M; Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Patel SJ; Center for Cell-Based Therapy, National Cancer Institute, Bethesda, MD 20892, USA.
  • Yu Z; Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Palmer DC; Center for Cell-Based Therapy, National Cancer Institute, Bethesda, MD 20892, USA.
  • Kruhlak MJ; Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Liu X; Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Locasale JW; Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Huang J; Center for Cell-Based Therapy, National Cancer Institute, Bethesda, MD 20892, USA.
  • Roychoudhuri R; Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Finkel T; Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Klebanoff CA; Center for Cell-Based Therapy, National Cancer Institute, Bethesda, MD 20892, USA.
  • Restifo NP; Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Science ; 363(6434)2019 03 29.
Article in En | MEDLINE | ID: mdl-30923193
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Potassium / Stem Cells / Lymphocytes, Tumor-Infiltrating / CD8-Positive T-Lymphocytes / Immune Tolerance / Neoplasms Limits: Animals / Humans Language: En Journal: Science Year: 2019 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Potassium / Stem Cells / Lymphocytes, Tumor-Infiltrating / CD8-Positive T-Lymphocytes / Immune Tolerance / Neoplasms Limits: Animals / Humans Language: En Journal: Science Year: 2019 Type: Article Affiliation country: United States