Neuroprotective Effects of an Aqueous Extract of <i>Forsythia viridissima</i> and Its Major Constituents on Oxaliplatin-Induced Peripheral Neuropathy.

Yi, Jin-Mu; Shin, Sarah; Kim, No Soo; Bang, Ok-Sun

Neuroprotective Effects of an Aqueous Extract of Forsythia viridissima and Its Major Constituents on Oxaliplatin-Induced Peripheral Neuropathy.

Yi, Jin-Mu; Shin, Sarah; Kim, No Soo; Bang, Ok-Sun.

Affiliation

Yi JM; Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea. jmyi@kiom.re.kr.
Shin S; Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea. s.sarah@kiom.re.kr.
Kim NS; Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea. nosookim@kiom.re.kr.
Bang OS; Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea. osbang@kiom.re.kr.

Molecules ; 24(6)2019 Mar 25.

Article in En | MEDLINE | ID: mdl-30934631

Subject(s)

Forsythia/chemistry; Neuroprotective Agents/chemistry; Neuroprotective Agents/pharmacology; Oxaliplatin/adverse effects; Peripheral Nervous System Diseases/etiology; Phytochemicals/chemistry; Plant Extracts/chemistry; Plant Extracts/pharmacology; Animals; Apoptosis/drug effects; Cell Line; Chromatography, High Pressure Liquid; Disease Models, Animal; Humans; Male; Membrane Potential, Mitochondrial/drug effects; Mice; Peripheral Nervous System Diseases/drug therapy; Peripheral Nervous System Diseases/pathology; Rats; Reactive Oxygen Species/metabolism

Key words

Forsythia viridissima; arctigenin; matairesinol; neuroprotection; oxaliplatin, oxaliplatin-induced peripheral neuropathy; von Frey test

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Extracts / Peripheral Nervous System Diseases / Neuroprotective Agents / Forsythia / Phytochemicals / Oxaliplatin Limits: Animals / Humans / Male Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2019 Type: Article

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