Micheliolide inhibits gastric cancer growth in vitro and in vivo via blockade of the IL-6/STAT3 pathway.

Tang, Xiaogang; Ding, Qiulong; Chen, Chao; Chen, Fei; Zhou, Xiyang; Hong, Chu Jie; Pan, Wensheng

Micheliolide inhibits gastric cancer growth in vitro and in vivo via blockade of the IL-6/STAT3 pathway.

Tang, Xiaogang; Ding, Qiulong; Chen, Chao; Chen, Fei; Zhou, Xiyang; Hong, Chu Jie; Pan, Wensheng.

Pharmazie ; 74(3): 175-178, 2019 03 01.

Article in En | MEDLINE | ID: mdl-30961685

Subject(s)

Interleukin-6/antagonists & inhibitors; STAT3 Transcription Factor/antagonists & inhibitors; Sesquiterpenes, Guaiane/pharmacology; Stomach Neoplasms/drug therapy; Animals; Apoptosis/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Humans; Interleukin-6/metabolism; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Random Allocation; STAT3 Transcription Factor/metabolism; Signal Transduction/drug effects; Stomach Neoplasms/metabolism; Stomach Neoplasms/pathology; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Interleukin-6 / Sesquiterpenes, Guaiane / STAT3 Transcription Factor Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans Language: En Journal: Pharmazie Journal subject: FARMACIA Year: 2019 Type: Article

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