Cell size sensing-a one-dimensional solution for a three-dimensional problem?
BMC Biol
; 17(1): 36, 2019 04 29.
Article
in En
| MEDLINE
| ID: mdl-31035993
ABSTRACT
Individual cell types have characteristic sizes, suggesting that size sensing mechanisms may coordinate transcription, translation, and metabolism with cell growth rates. Two types of size-sensing mechanisms have been proposed spatial sensing of the location or dimensions of a signal, subcellular structure or organelle; or titration-based sensing of the intracellular concentrations of key regulators. Here we propose that size sensing in animal cells combines both titration and spatial sensing elements in a dynamic mechanism whereby microtubule motor-dependent localization of RNA encoding importin ß1 and mTOR, coupled with regulated local protein synthesis, enable cytoskeleton length sensing for cell growth regulation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Physiological Phenomena
/
Feedback, Physiological
/
Cell Size
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
BMC Biol
Journal subject:
BIOLOGIA
Year:
2019
Type:
Article
Affiliation country:
Israel