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A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.
Polykratis, Apostolos; Martens, Arne; Eren, Remzi Onur; Shirasaki, Yoshitaka; Yamagishi, Mai; Yamaguchi, Yoshifumi; Uemura, Sotaro; Miura, Masayuki; Holzmann, Bernhard; Kollias, George; Armaka, Marietta; van Loo, Geert; Pasparakis, Manolis.
Affiliation
  • Polykratis A; Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine, University of Cologne, Cologne, Germany.
  • Martens A; VIB Center for Inflammation Research, Ghent, Belgium.
  • Eren RO; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
  • Shirasaki Y; Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine, University of Cologne, Cologne, Germany.
  • Yamagishi M; Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Tokyo, Japan.
  • Yamaguchi Y; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
  • Uemura S; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
  • Miura M; Department of Genetics, Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan.
  • Holzmann B; Institute of Low Temperature Science, Hokkaido University, Sapporo, Japan.
  • Kollias G; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
  • Armaka M; Department of Genetics, Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan.
  • van Loo G; Department of Surgery, School of Medicine, Technical University of Munich, Munich, Germany.
  • Pasparakis M; Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece.
Nat Cell Biol ; 21(6): 731-742, 2019 06.
Article in En | MEDLINE | ID: mdl-31086261
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis / Kruppel-Like Transcription Factors / Tumor Necrosis Factor alpha-Induced Protein 3 / Inflammation Limits: Animals / Humans Language: En Journal: Nat Cell Biol Year: 2019 Type: Article Affiliation country: Germany
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis / Kruppel-Like Transcription Factors / Tumor Necrosis Factor alpha-Induced Protein 3 / Inflammation Limits: Animals / Humans Language: En Journal: Nat Cell Biol Year: 2019 Type: Article Affiliation country: Germany