Genetic Regulation of Streptococci by Small RNAs.
Curr Issues Mol Biol
; 32: 39-86, 2019.
Article
in En
| MEDLINE
| ID: mdl-31166169
ABSTRACT
Streptococcal species constitute a large group of commensal and pathogenic Gram-positive bacteria that exist in a wide variety of habitats. The family of small RNAs is typically ranged in size from 50 to 300 nucleotides, and acts as regulators in bacteria. The last decade has witnessed the increasing findings of small RNAs (sRNAs), which play important regulatory roles in the variety of biological processes in streptococci. In this review, we summarized the recent achievements in the identification of streptococcal sRNAs, mainly in Streptococcus pyogenes and Streptococcus pneumoniae. In addition, we particularly focused on the functions that sRNAs exert in the regulatory networks of both phenotypical traits and pathogenicity. The fact that sRNAs act as a critical fine-tuning regulator of streptococci may not only reveal in-depth mechanisms of bacterial post-transcriptional regulations in response to environmental perturbance, but also provide promising approaches to the better management of streptococcal infections.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Streptococcus pneumoniae
/
Streptococcus pyogenes
/
RNA, Bacterial
/
Gene Expression Regulation, Bacterial
/
Gene Regulatory Networks
/
RNA, Small Untranslated
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Curr Issues Mol Biol
Journal subject:
BIOLOGIA MOLECULAR
Year:
2019
Type:
Article
Affiliation country:
China