DSCR1-mediated TET1 splicing regulates miR-124 expression to control adult hippocampal neurogenesis.

Choi, Chiyeol; Kim, Taehoon; Chang, Karen T; Min, Kyung-Tai

Choi, Chiyeol; Kim, Taehoon; Chang, Karen T; Min, Kyung-Tai.

Affiliation

Choi C; Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea.
Kim T; National Creative Research Initiative Center for Proteostasis, Ulsan National Institute of Science and Technology, Ulsan, Korea.
Chang KT; Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea.
Min KT; National Creative Research Initiative Center for Proteostasis, Ulsan National Institute of Science and Technology, Ulsan, Korea.

EMBO J ; 38(14): e101293, 2019 07 15.

Article in En | MEDLINE | ID: mdl-31304631

Subject(s)

DNA-Binding Proteins/metabolism; Down Syndrome/genetics; Hippocampus/cytology; MicroRNAs/genetics; Mixed Function Oxygenases/genetics; Muscle Proteins/metabolism; Proto-Oncogene Proteins/genetics; RNA Splicing; Animals; Cells, Cultured; DNA-Binding Proteins/genetics; Disease Models, Animal; Down Syndrome/metabolism; Epigenesis, Genetic; Gene Knockdown Techniques; Hippocampus/metabolism; Humans; Male; Mice; Mice, Transgenic; Muscle Proteins/genetics; Mutation; Neurogenesis; Promoter Regions, Genetic

Key words

DSCR1; Down syndrome; TET1; adult hippocampal neurogenesis; miR-124

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA Splicing / Proto-Oncogene Proteins / Down Syndrome / MicroRNAs / DNA-Binding Proteins / Hippocampus / Mixed Function Oxygenases / Muscle Proteins Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: EMBO J Year: 2019 Type: Article

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