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Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet.
Luo, Yongde; Yang, Yaying; Liu, Muyun; Wang, Dan; Wang, Feng; Bi, Yawei; Ji, Juntao; Li, Suyun; Liu, Yan; Chen, Rong; Huang, Haojie; Wang, Xiaojie; Swidnicka-Siergiejko, Agnieszka K; Janowitz, Tobias; Beyaz, Semir; Wang, Guoqiang; Xu, Sulan; Bialkowska, Agnieszka B; Luo, Catherine K; Pin, Christoph L; Liang, Guang; Lu, Xiongbin; Wu, Maoxin; Shroyer, Kenneth R; Wolff, Robert A; Plunkett, William; Ji, Baoan; Li, Zhaoshen; Li, Ellen; Li, Xiaokun; Yang, Vincent W; Logsdon, Craig D; Abbruzzese, James L; Lu, Weiqin.
Affiliation
  • Luo Y; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China; Department of Medicine, Stony Brook University, Stony Brook, New York. Electronic address: yongdeluo08@gmail.com.
  • Yang Y; Department of Gastrointestinal Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas.
  • Liu M; Department of Gastrointestinal Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas.
  • Wang D; Department of Medicine, Stony Brook University, Stony Brook, New York.
  • Wang F; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
  • Bi Y; Department of Medicine, Stony Brook University, Stony Brook, New York.
  • Ji J; Department of Medicine, Stony Brook University, Stony Brook, New York.
  • Li S; Department of Medicine, Stony Brook University, Stony Brook, New York.
  • Liu Y; Department of Cancer Biology, University of Texas, MD Anderson Cancer Center, Houston, Texas.
  • Chen R; Department of Experimental Therapeutics, University of Texas, MD Anderson Cancer Center, Houston, Texas.
  • Huang H; Department of Cancer Biology, University of Texas, MD Anderson Cancer Center, Houston, Texas.
  • Wang X; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Swidnicka-Siergiejko AK; Department of Cancer Biology, University of Texas, MD Anderson Cancer Center, Houston, Texas.
  • Janowitz T; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
  • Beyaz S; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
  • Wang G; Department of Medicine, Stony Brook University, Stony Brook, New York.
  • Xu S; Department of Medicine, Stony Brook University, Stony Brook, New York.
  • Bialkowska AB; Department of Medicine, Stony Brook University, Stony Brook, New York.
  • Luo CK; Department of Medicine, Stony Brook University, Stony Brook, New York.
  • Pin CL; Departments of Pediatrics, Oncology, and Physiology and Pharmacology, Schulich School of Medicine, University of Western Ontario Children's Health Research Institute, London, Ontario, Canada.
  • Liang G; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Lu X; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.
  • Wu M; Department of Pathology, Stony Brook University, Stony Brook, New York.
  • Shroyer KR; Department of Pathology, Stony Brook University, Stony Brook, New York.
  • Wolff RA; Department of Gastrointestinal Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas.
  • Plunkett W; Department of Experimental Therapeutics, University of Texas, MD Anderson Cancer Center, Houston, Texas.
  • Ji B; Department of Biochemistry and Molecular Biology, Mayo Clinic, Jacksonville, Florida.
  • Li Z; Department of Gastroenterology, Changhai Hospital, Shanghai, China.
  • Li E; Department of Medicine, Stony Brook University, Stony Brook, New York.
  • Li X; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Yang VW; Department of Medicine, Stony Brook University, Stony Brook, New York.
  • Logsdon CD; Department of Gastrointestinal Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas; Department of Cancer Biology, University of Texas, MD Anderson Cancer Center, Houston, Texas.
  • Abbruzzese JL; Department of Gastrointestinal Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas; Division of Medical Oncology, Department of Medicine, Duke Cancer Institute, Duke University, Durham, North Carolina.
  • Lu W; Department of Medicine, Stony Brook University, Stony Brook, New York; Department of Gastrointestinal Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas. Electronic address: weiqin.lu@stonybrookmedicine.edu.
Gastroenterology ; 157(5): 1413-1428.e11, 2019 11.
Article in En | MEDLINE | ID: mdl-31352001
Subject(s)
Acinar Cells/metabolism; Carcinoma, Pancreatic Ductal/metabolism; Cell Transformation, Neoplastic/metabolism; Diet, High-Fat; Fibroblast Growth Factors/metabolism; Pancreatic Intraductal Neoplasms/metabolism; Pancreatic Neoplasms/metabolism; Proto-Oncogene Proteins p21(ras)/metabolism; Acinar Cells/pathology; Animals; Carcinoma, Pancreatic Ductal/genetics; Carcinoma, Pancreatic Ductal/pathology; Carcinoma, Pancreatic Ductal/prevention & control; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/pathology; Down-Regulation; Fibroblast Growth Factors/genetics; Gene Expression Regulation, Neoplastic; Humans; Klotho Proteins; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mice, Transgenic; Mutation; PPAR gamma/genetics; PPAR gamma/metabolism; Pancreatic Cyst/genetics; Pancreatic Cyst/metabolism; Pancreatic Cyst/pathology; Pancreatic Intraductal Neoplasms/genetics; Pancreatic Intraductal Neoplasms/pathology; Pancreatic Intraductal Neoplasms/prevention & control; Pancreatic Neoplasms/genetics; Pancreatic Neoplasms/pathology; Pancreatic Neoplasms/prevention & control; Pancreatitis/genetics; Pancreatitis/metabolism; Pancreatitis/pathology; Proto-Oncogene Proteins p21(ras)/genetics; Receptor, Fibroblast Growth Factor, Type 1/genetics; Receptor, Fibroblast Growth Factor, Type 1/metabolism; Signal Transduction; Transcription Factors/genetics; Transcription Factors/metabolism; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Cell Transformation, Neoplastic / Proto-Oncogene Proteins p21(ras) / Carcinoma, Pancreatic Ductal / Acinar Cells / Diet, High-Fat / Fibroblast Growth Factors / Pancreatic Intraductal Neoplasms Type of study: Risk_factors_studies Language: En Journal: Gastroenterology Year: 2019 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Cell Transformation, Neoplastic / Proto-Oncogene Proteins p21(ras) / Carcinoma, Pancreatic Ductal / Acinar Cells / Diet, High-Fat / Fibroblast Growth Factors / Pancreatic Intraductal Neoplasms Type of study: Risk_factors_studies Language: En Journal: Gastroenterology Year: 2019 Type: Article