G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel.

Lagman, Joann; Sayegh, Paula; Lee, Christina S; Sulon, Sarah M; Jacinto, Alec Z; Sok, Vanessa; Peng, Natalie; Alp, Deniz; Benovic, Jeffrey L; So, Christopher H

Lagman, Joann; Sayegh, Paula; Lee, Christina S; Sulon, Sarah M; Jacinto, Alec Z; Sok, Vanessa; Peng, Natalie; Alp, Deniz; Benovic, Jeffrey L; So, Christopher H.

Affiliation

Lagman J; Roseman University of Health Sciences School of Pharmacy, 11 Sunset Way, Henderson, NV, 89014, USA.
Sayegh P; Roseman University of Health Sciences School of Pharmacy, 11 Sunset Way, Henderson, NV, 89014, USA.
Lee CS; Roseman University of Health Sciences School of Pharmacy, 11 Sunset Way, Henderson, NV, 89014, USA.
Sulon SM; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Jacinto AZ; Roseman University of Health Sciences School of Pharmacy, 11 Sunset Way, Henderson, NV, 89014, USA.
Sok V; Roseman University of Health Sciences School of Pharmacy, 11 Sunset Way, Henderson, NV, 89014, USA.
Peng N; Roseman University of Health Sciences School of Pharmacy, 11 Sunset Way, Henderson, NV, 89014, USA.
Alp D; Roseman University of Health Sciences School of Pharmacy, 11 Sunset Way, Henderson, NV, 89014, USA.
Benovic JL; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
So CH; Roseman University of Health Sciences School of Pharmacy, 11 Sunset Way, Henderson, NV, 89014, USA. cso@roseman.edu.

Mol Cell Biochem ; 461(1-2): 103-118, 2019 Nov.

Article in En | MEDLINE | ID: mdl-31363957

Subject(s)

Drug Resistance, Neoplasm/drug effects; G-Protein-Coupled Receptor Kinase 5/metabolism; Paclitaxel/pharmacology; Acetylation; Apoptosis/drug effects; Biocatalysis/drug effects; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Docetaxel/pharmacology; Female; G-Protein-Coupled Receptor Kinase 3/metabolism; G-Protein-Coupled Receptor Kinases/metabolism; HeLa Cells; Histone Deacetylase 6/metabolism; Histones/metabolism; Humans; MAP Kinase Signaling System/drug effects; Phosphorylation/drug effects; Phosphoserine/metabolism; Protein Binding/drug effects; Tubulin/metabolism

Key words

Acetylation; Cancer; G protein-coupled receptor kinase; Histone deacetylase; Paclitaxel

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paclitaxel / Drug Resistance, Neoplasm / G-Protein-Coupled Receptor Kinase 5 Limits: Female / Humans Language: En Journal: Mol Cell Biochem Year: 2019 Type: Article Affiliation country: United States

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