Pharmacokinetic and Safety Profiles of a Fixed-Dose Combination of Amlodipine, Valsartan, and Atorvastatin: A 3-Period Replicate Crossover Study.

Kim, Seokuee; Ko, Jae-Wook; Kim, Jung-Ryul

Kim, Seokuee; Ko, Jae-Wook; Kim, Jung-Ryul.

Affiliation

Kim S; Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, Seoul, Republic of Korea.
Ko JW; Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, Seoul, Republic of Korea.
Kim JR; Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, Seoul, Republic of Korea.

Clin Pharmacol Drug Dev ; 9(3): 386-394, 2020 04.

Article in En | MEDLINE | ID: mdl-31373174

Subject(s)

Amlodipine/administration & dosage; Atorvastatin/administration & dosage; Valsartan/administration & dosage; Adult; Amlodipine/adverse effects; Amlodipine/pharmacokinetics; Amlodipine, Valsartan Drug Combination/administration & dosage; Amlodipine, Valsartan Drug Combination/adverse effects; Amlodipine, Valsartan Drug Combination/pharmacokinetics; Antihypertensive Agents/administration & dosage; Antihypertensive Agents/adverse effects; Antihypertensive Agents/pharmacokinetics; Area Under Curve; Atorvastatin/adverse effects; Atorvastatin/pharmacokinetics; Cross-Over Studies; Drug Combinations; Humans; Male; Therapeutic Equivalency; Valsartan/adverse effects; Valsartan/pharmacokinetics; Young Adult

Key words

atorvastatin; fixed-dose combination; highly variable drug; replicate crossover; within-subject variability

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amlodipine / Atorvastatin / Valsartan Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Humans / Male Language: En Journal: Clin Pharmacol Drug Dev Year: 2020 Type: Article

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