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Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.
Oellerich, Thomas; Schneider, Constanze; Thomas, Dominique; Knecht, Kirsten M; Buzovetsky, Olga; Kaderali, Lars; Schliemann, Christoph; Bohnenberger, Hanibal; Angenendt, Linus; Hartmann, Wolfgang; Wardelmann, Eva; Rothenburger, Tamara; Mohr, Sebastian; Scheich, Sebastian; Comoglio, Federico; Wilke, Anne; Ströbel, Philipp; Serve, Hubert; Michaelis, Martin; Ferreirós, Nerea; Geisslinger, Gerd; Xiong, Yong; Keppler, Oliver T; Cinatl, Jindrich.
Affiliation
  • Oellerich T; Department of Medicine II, Hematology/Oncology, Goethe University of Frankfurt, Frankfurt, 60590, Germany.
  • Schneider C; German Cancer Consortium/German Cancer Research Center, Heidelberg, 69120, Germany.
  • Thomas D; Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt, 60596, Germany.
  • Knecht KM; Department of Medicine II, Hematology/Oncology, Goethe University of Frankfurt, Frankfurt, 60590, Germany.
  • Buzovetsky O; Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt, 60596, Germany.
  • Kaderali L; Institute of Medical Virology, University of Frankfurt, Frankfurt, 60590, Germany.
  • Schliemann C; pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University of Frankfurt, Frankfurt, 60590, Germany.
  • Bohnenberger H; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA.
  • Angenendt L; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA.
  • Hartmann W; Institute of Bioinformatics, University Medicine Greifswald, Greifswald, 17475, Germany.
  • Wardelmann E; Department of Medicine A, University Hospital Münster, Münster, 48149, Germany.
  • Rothenburger T; Institute of Pathology, University Medical Center, Göttingen, 37075, Germany.
  • Mohr S; Department of Medicine A, University Hospital Münster, Münster, 48149, Germany.
  • Scheich S; Gerhard Domagk Institute for Pathology, University Hospital Münster, Münster, 48149, Germany.
  • Comoglio F; Gerhard Domagk Institute for Pathology, University Hospital Münster, Münster, 48149, Germany.
  • Wilke A; Institute of Medical Virology, University of Frankfurt, Frankfurt, 60590, Germany.
  • Ströbel P; Department of Medicine II, Hematology/Oncology, Goethe University of Frankfurt, Frankfurt, 60590, Germany.
  • Serve H; Department of Medicine II, Hematology/Oncology, Goethe University of Frankfurt, Frankfurt, 60590, Germany.
  • Michaelis M; Department of Haematology, Cambridge Institute of Medical Research, Cambridge University, Cambridge, CB2 0XY, UK.
  • Ferreirós N; Department of Medicine II, Hematology/Oncology, Goethe University of Frankfurt, Frankfurt, 60590, Germany.
  • Geisslinger G; Institute of Pathology, University Medical Center, Göttingen, 37075, Germany.
  • Xiong Y; Department of Medicine II, Hematology/Oncology, Goethe University of Frankfurt, Frankfurt, 60590, Germany.
  • Keppler OT; German Cancer Consortium/German Cancer Research Center, Heidelberg, 69120, Germany.
  • Cinatl J; Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt, 60596, Germany.
Nat Commun ; 10(1): 3475, 2019 08 02.
Article in En | MEDLINE | ID: mdl-31375673
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Biomarkers, Tumor / Drug Resistance, Neoplasm / SAM Domain and HD Domain-Containing Protein 1 / Antimetabolites, Antineoplastic Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Type: Article Affiliation country: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Biomarkers, Tumor / Drug Resistance, Neoplasm / SAM Domain and HD Domain-Containing Protein 1 / Antimetabolites, Antineoplastic Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Type: Article Affiliation country: Germany