Dihydroartemisinin suppresses glycolysis of LNCaP cells by inhibiting PI3K/AKT pathway and downregulating HIF-1&#945; expression.

Zhu, Wenhe; Li, Yawei; Zhao, Donghai; Li, Huilin; Zhang, Wei; Xu, Junjie; Hou, Jiancheng; Feng, Xianmin; Wang, Huiyan

Dihydroartemisinin suppresses glycolysis of LNCaP cells by inhibiting PI3K/AKT pathway and downregulating HIF-1α expression.

Zhu, Wenhe; Li, Yawei; Zhao, Donghai; Li, Huilin; Zhang, Wei; Xu, Junjie; Hou, Jiancheng; Feng, Xianmin; Wang, Huiyan.

Affiliation

Zhu W; Jilin Medical University, Ji Lin, China.
Li Y; Jilin Medical University, Ji Lin, China.
Zhao D; Jilin Medical University, Ji Lin, China.
Li H; Jilin Medical University, Ji Lin, China.
Zhang W; Jilin Medical University, Ji Lin, China.
Xu J; Jilin Medical University, Ji Lin, China.
Hou J; Jilin Medical University, Ji Lin, China.
Feng X; Jilin Medical University, Ji Lin, China.
Wang H; Jilin Medical University, Ji Lin, China. Electronic address: jlmpcwhy@163.com.

Life Sci ; 233: 116730, 2019 Sep 15.

Article in En | MEDLINE | ID: mdl-31390552

Subject(s)

Artemisinins/pharmacology; Biomarkers, Tumor/metabolism; Glycolysis/drug effects; Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors; Phosphoinositide-3 Kinase Inhibitors; Prostatic Neoplasms/drug therapy; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Antimalarials/pharmacology; Apoptosis; Biomarkers, Tumor/genetics; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Male; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/metabolism; Prostatic Neoplasms/metabolism; Prostatic Neoplasms/pathology; Proto-Oncogene Proteins c-akt/genetics; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction; Tumor Cells, Cultured

Key words

Akt/mTOR; Dihydroartemisinin; Glycolysis; HIF-1 α; Prostate cancer

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Biomarkers, Tumor / Artemisinins / Proto-Oncogene Proteins c-akt / Hypoxia-Inducible Factor 1, alpha Subunit / Phosphoinositide-3 Kinase Inhibitors / Glycolysis Limits: Humans / Male Language: En Journal: Life Sci Year: 2019 Type: Article Affiliation country: China

Fulltext

XML

PubMed Links

Search on Google