Computational framework for predictive PBPK-PD-Tox simulations of opioids and antidotes.

German, Carrie; Pilvankar, Minu; Przekwas, Andrzej

German, Carrie; Pilvankar, Minu; Przekwas, Andrzej.

Affiliation

German C; CFD Research Corp., Huntsville, AL, 35806, USA. carrie.german@cfdrc.com.
Pilvankar M; School of Chemical Engineering, Oklahoma State University, Stillwater, OK, 74078, USA.
Przekwas A; CFD Research Corp., Huntsville, AL, 35806, USA.

J Pharmacokinet Pharmacodyn ; 46(6): 513-529, 2019 12.

Article in En | MEDLINE | ID: mdl-31396799

Subject(s)

Analgesics, Opioid/adverse effects; Analgesics, Opioid/pharmacokinetics; Antidotes/adverse effects; Antidotes/pharmacokinetics; Analgesics, Opioid/administration & dosage; Antidotes/administration & dosage; Humans; Male; Morphine/adverse effects; Morphine/pharmacokinetics; Naloxone/administration & dosage; Naloxone/adverse effects; Naloxone/pharmacokinetics; Narcotic Antagonists/administration & dosage; Narcotic Antagonists/adverse effects; Narcotic Antagonists/pharmacokinetics; Opioid-Related Disorders/drug therapy; Pain/drug therapy; Receptors, Opioid/metabolism

Key words

Modeling; Naloxone; Opioids; PBPK; Pharmacodynamics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Analgesics, Opioid / Antidotes Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans / Male Language: En Journal: J Pharmacokinet Pharmacodyn Journal subject: FARMACOLOGIA Year: 2019 Type: Article Affiliation country: United States

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