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Novel ADAM-17 inhibitor ZLDI-8 inhibits the proliferation and metastasis of chemo-resistant non-small-cell lung cancer by reversing Notch and epithelial mesenchymal transition in vitro and in vivo.
Lu, Hong-Yuan; Zu, Yu-Xin; Jiang, Xiao-Wen; Sun, Xiao-Tong; Liu, Tian-Yi; Li, Ruo-Lan; Wu, Qiong; Zhang, Ying-Shi; Zhao, Qing-Chun.
Affiliation
  • Lu HY; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110840, China.
  • Zu YX; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Jiang XW; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Sun XT; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Liu TY; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Li RL; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Wu Q; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Zhang YS; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: zhangyingshi526@163.com.
  • Zhao QC; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110840, China. Electronic address: zhaoqingchun1967@163.com.
Pharmacol Res ; 148: 104406, 2019 10.
Article in En | MEDLINE | ID: mdl-31442576
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Drug Resistance, Neoplasm / Cell Proliferation / Epithelial-Mesenchymal Transition / ADAM17 Protein / Lung Neoplasms / Neoplasm Metastasis / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2019 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Drug Resistance, Neoplasm / Cell Proliferation / Epithelial-Mesenchymal Transition / ADAM17 Protein / Lung Neoplasms / Neoplasm Metastasis / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2019 Type: Article Affiliation country: China