Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase.

Wu, Jinjun; Samara, Nadine L; Kuraoka, Isao; Yang, Wei

Wu, Jinjun; Samara, Nadine L; Kuraoka, Isao; Yang, Wei.

Affiliation

Wu J; Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD 20892, USA.
Samara NL; Section on Biological Chemistry, NIDCR, NIH, Bethesda, MD 20892, USA.
Kuraoka I; Department of Chemistry, Faculty of Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Yang W; Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD 20892, USA. Electronic address: wei.yang@nih.gov.

Mol Cell ; 76(1): 44-56.e3, 2019 10 03.

Article in En | MEDLINE | ID: mdl-31444105

Subject(s)

Bacterial Proteins/metabolism; DNA Repair; DNA, Bacterial/metabolism; Deoxyribonuclease (Pyrimidine Dimer)/metabolism; Evolution, Molecular; Inosine/metabolism; RNA/metabolism; Ribonuclease H/metabolism; Animals; Argonaute Proteins/metabolism; Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Catalysis; DNA, Bacterial/chemistry; DNA, Bacterial/genetics; Deoxyribonuclease (Pyrimidine Dimer)/chemistry; Deoxyribonuclease (Pyrimidine Dimer)/genetics; Humans; Magnesium/metabolism; Manganese/metabolism; Mice; Nucleic Acid Conformation; Protein Conformation; RNA/chemistry; RNA/genetics; Ribonuclease H/chemistry; Ribonuclease H/genetics; Structure-Activity Relationship; Substrate Specificity

Key words

DNase; RNase; adenosine deamination; catalysis; evolution; metal ion; ribonucleotide recognition

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / DNA, Bacterial / RNA / Ribonuclease H / Evolution, Molecular / Deoxyribonuclease (Pyrimidine Dimer) / DNA Repair / Inosine Limits: Animals / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2019 Type: Article Affiliation country: United States

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