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PI3K/AKT inhibitors aggravate death receptor-mediated hepatocyte apoptosis and liver injury.
Liu, Wei; Jing, Zhen-Tang; Xue, Chao-Rong; Wu, Shu-Xiang; Chen, Wan-Nan; Lin, Xin-Jian; Lin, Xu.
Affiliation
  • Liu W; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China; Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, China.
  • Jing ZT; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China.
  • Xue CR; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China.
  • Wu SX; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China.
  • Chen WN; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China; Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, China.
  • Lin XJ; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China.
  • Lin X; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China; Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, China. Electronic address: linxu@mail.fjmu.edu.cn.
Toxicol Appl Pharmacol ; 381: 114729, 2019 10 15.
Article in En | MEDLINE | ID: mdl-31445927
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Hepatocytes / Protein Kinase Inhibitors / Proto-Oncogene Proteins c-akt / Chemical and Drug Induced Liver Injury / Phosphoinositide-3 Kinase Inhibitors Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Toxicol Appl Pharmacol Year: 2019 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Hepatocytes / Protein Kinase Inhibitors / Proto-Oncogene Proteins c-akt / Chemical and Drug Induced Liver Injury / Phosphoinositide-3 Kinase Inhibitors Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Toxicol Appl Pharmacol Year: 2019 Type: Article Affiliation country: China