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Ubiquitin C-Terminal Hydrolase L1: Biochemical and Cellular Characterization of a Covalent Cyanopyrrolidine-Based Inhibitor.
Krabill, Aaron D; Chen, Hao; Hussain, Sajjad; Feng, Chao; Abdullah, Ammara; Das, Chittaranjan; Aryal, Uma K; Post, Carol Beth; Wendt, Michael K; Galardy, Paul J; Flaherty, Daniel P.
Affiliation
  • Krabill AD; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Dr., West Lafayette, IN, 47907, USA.
  • Chen H; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Dr., West Lafayette, IN, 47907, USA.
  • Hussain S; Division of Pediatric Hematology-Oncology, Mayo Clinic, 200 First St. SW, Guggenheim 15, Rochester, MN, 55905, USA.
  • Feng C; Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First St. SW, Guggenheim 15, Rochester, MN, 55905, USA.
  • Abdullah A; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Dr., West Lafayette, IN, 47907, USA.
  • Das C; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Dr., West Lafayette, IN, 47907, USA.
  • Aryal UK; Department of Chemistry, College of Science, Purdue University, 560 Oval, West Lafayette, IN, 47907, USA.
  • Post CB; Purdue Proteomics Facility, Bindley Biosciences Center, Purdue University, 1275 3rd St., West Lafayette, IN, 47907, USA.
  • Wendt MK; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Dr., West Lafayette, IN, 47907, USA.
  • Galardy PJ; Department of Biological Sciences, Markey Center for Structural Biology, Purdue University, 915 W State St., West Lafayette, IN, 47907, USA.
  • Flaherty DP; Purdue Institute for Drug Discovery, 720 Clinic Dr., West Lafayette, IN, 47907, USA.
Chembiochem ; 21(5): 712-722, 2020 03 02.
Article in En | MEDLINE | ID: mdl-31449350
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin Thiolesterase / Enzyme Inhibitors Limits: Humans Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2020 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin Thiolesterase / Enzyme Inhibitors Limits: Humans Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2020 Type: Article Affiliation country: United States