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Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome.
Panagaki, Theodora; Randi, Elisa B; Augsburger, Fiona; Szabo, Csaba.
Affiliation
  • Panagaki T; Chair of Pharmacology, Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland.
  • Randi EB; Chair of Pharmacology, Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland.
  • Augsburger F; Chair of Pharmacology, Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland.
  • Szabo C; Chair of Pharmacology, Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland csaba.szabo@unifr.ch.
Proc Natl Acad Sci U S A ; 116(38): 18769-18771, 2019 09 17.
Article in En | MEDLINE | ID: mdl-31481613
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Down Syndrome / Electron Transport Complex IV / Cystathionine beta-Synthase / Hydrogen Sulfide / Mitochondria Limits: Female / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2019 Type: Article Affiliation country: Switzerland
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Down Syndrome / Electron Transport Complex IV / Cystathionine beta-Synthase / Hydrogen Sulfide / Mitochondria Limits: Female / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2019 Type: Article Affiliation country: Switzerland