First Results from a Screening of 300 Naturally Occurring Compounds: 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol, 4,5,6-tribromo-2-(2',4'-dibromophenoxy)phenol, and 5-epi-nakijinone Q as Substances with the Potential for Anticancer Therapy.

Mayer, Saskia; Prechtl, Marie; Liebfried, Pia; Cadeddu, Ron-Patrick; Stuhldreier, Fabian; Kohl, Matthias; Wenzel, Folker; Stork, Björn; Wesselborg, Sebastian; Proksch, Peter; Germing, Ulrich; Haas, Rainer; Jäger, Paul

Mayer, Saskia; Prechtl, Marie; Liebfried, Pia; Cadeddu, Ron-Patrick; Stuhldreier, Fabian; Kohl, Matthias; Wenzel, Folker; Stork, Björn; Wesselborg, Sebastian; Proksch, Peter; Germing, Ulrich; Haas, Rainer; Jäger, Paul.

Affiliation

Mayer S; Faculty Medical and Life Sciences, Campus Villingen-Schwenningen, Hochschule Furtwangen University, 78120 Furtwangen, Germany. Mayer.Saskia@gmx.net.
Prechtl M; Faculty Medical and Life Sciences, Campus Villingen-Schwenningen, Hochschule Furtwangen University, 78120 Furtwangen, Germany. marie.prechtl97@gmx.de.
Liebfried P; Department of Hematology, Oncology and Clinical Immunology, University Hospital Düsseldorf, 40225 Düsseldorf, Germany. Pia.Liebfried@ucb.com.
Cadeddu RP; Department of Hematology, Oncology and Clinical Immunology, University Hospital Düsseldorf, 40225 Düsseldorf, Germany. Ron-Patrick.Cadeddu@med.uni-duesseldorf.de.
Stuhldreier F; Institute for Molecular Medicine I, University Hospital Düsseldorf, 40225 Düsseldorf, Germany. Fabian.Stuhldreier@uni-duesseldorf.de.
Kohl M; Faculty Medical and Life Sciences, Campus Villingen-Schwenningen, Hochschule Furtwangen University, 78120 Furtwangen, Germany. kohl@hs-furtwangen.de.
Wenzel F; Faculty Medical and Life Sciences, Campus Villingen-Schwenningen, Hochschule Furtwangen University, 78120 Furtwangen, Germany. Folker.Wenzel@hs-furtwangen.de.
Stork B; Institute for Molecular Medicine I, University Hospital Düsseldorf, 40225 Düsseldorf, Germany. bjoern.stork@uni-duesseldorf.de.
Wesselborg S; Institute for Molecular Medicine I, University Hospital Düsseldorf, 40225 Düsseldorf, Germany. sebastian.wesselborg@uni-duesseldorf.de.
Proksch P; Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, 40225 Düsseldorf, Germany. Peter.Proksch@hhu.de.
Germing U; Department of Hematology, Oncology and Clinical Immunology, University Hospital Düsseldorf, 40225 Düsseldorf, Germany. Germing@med.uni-duesseldorf.de.
Haas R; Department of Hematology, Oncology and Clinical Immunology, University Hospital Düsseldorf, 40225 Düsseldorf, Germany. Haas@med.uni-duesseldorf.de.
Jäger P; Department of Hematology, Oncology and Clinical Immunology, University Hospital Düsseldorf, 40225 Düsseldorf, Germany. PaulSebastian.Jaeger@med.uni-duesseldorf.de.

Mar Drugs ; 17(9)2019 Sep 05.

Article in En | MEDLINE | ID: mdl-31491907

Subject(s)

Antineoplastic Agents/therapeutic use; Phenol/therapeutic use; Adult; Aged; Apoptosis/drug effects; Cell Line, Tumor; Female; HL-60 Cells; Hematopoietic Stem Cells/drug effects; Humans; Jurkat Cells; Leukemia, Myeloid, Acute/drug therapy; Leukocytes, Mononuclear/drug effects; Male; Middle Aged; THP-1 Cells

Key words

acute myeloid leukemia; apoptosis; bioactive natural products; cytotoxic activity; drug leads; marine sponge derived natural products; peripheral blood mononuclear cells; polybrominated diphenyl ethers; primary leukemic cells; sesquiterpene aminoquinone

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenol / Antineoplastic Agents Type of study: Diagnostic_studies / Screening_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2019 Type: Article Affiliation country: Germany

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