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Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis.
Anderson, Niall A; Campos, Sebastien; Butler, Sharon; Copley, Royston C B; Duncan, Ian; Harrison, Stephen; Le, Joelle; Maghames, Rosemary; Pastor-Garcia, Aleix; Pritchard, John M; Rowedder, James E; Smith, Claire E; Thomas, Jack; Vitulli, Giovanni; Macdonald, Simon J F.
Affiliation
  • Anderson NA; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Campos S; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Butler S; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Copley RCB; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Duncan I; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Harrison S; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Le J; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Maghames R; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Pastor-Garcia A; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Pritchard JM; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Rowedder JE; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Smith CE; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Thomas J; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Vitulli G; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Macdonald SJF; GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
J Med Chem ; 62(19): 8796-8808, 2019 10 10.
Article in En | MEDLINE | ID: mdl-31497959
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylbutyrates / Integrin alphaV / Idiopathic Pulmonary Fibrosis Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2019 Type: Article Affiliation country: United kingdom
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylbutyrates / Integrin alphaV / Idiopathic Pulmonary Fibrosis Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2019 Type: Article Affiliation country: United kingdom