Integrating physiologically based kinetic (PBK) and Monte Carlo modelling to predict inter-individual and inter-ethnic variation in bioactivation and liver toxicity of lasiocarpine.

Ning, Jia; Rietjens, Ivonne M C M; Strikwold, Marije

Ning, Jia; Rietjens, Ivonne M C M; Strikwold, Marije.

Affiliation

Ning J; Division of Toxicology, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The Netherlands. jia.ning@wur.nl.
Rietjens IMCM; Division of Toxicology, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
Strikwold M; Van Hall Larenstein University of Applied Sciences, PO Box 1528, 8901 BV, Leeuwarden, The Netherlands.

Arch Toxicol ; 93(10): 2943-2960, 2019 10.

Article in En | MEDLINE | ID: mdl-31511935

Subject(s)

Asian People; Chemical and Drug Induced Liver Injury/etiology; Models, Biological; Pyrrolizidine Alkaloids/pharmacokinetics; White People; Animals; Chemical and Drug Induced Liver Injury/ethnology; Computer Simulation; Glutathione/chemistry; Humans; Male; Microsomes, Liver/drug effects; Microsomes, Liver/metabolism; Monte Carlo Method; Pyrrolizidine Alkaloids/toxicity; Risk Assessment/methods

Key words

Chemical specific adjustment factors; Inter-ethnic; Lasiocarpine; Monte Carlo simulations; Physiologically based kinetic (PBK) model; Pyrrole glutathione adduct

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolizidine Alkaloids / Asian People / White People / Chemical and Drug Induced Liver Injury / Models, Biological Type of study: Etiology_studies / Health_economic_evaluation / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: Arch Toxicol Year: 2019 Type: Article Affiliation country: Netherlands

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