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Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death.
Jiang, Hui; Xue, Xiaoyu; Panda, Swarupa; Kawale, Ajinkya; Hooy, Richard M; Liang, Fengshan; Sohn, Jungsan; Sung, Patrick; Gekara, Nelson O.
Affiliation
  • Jiang H; The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.
  • Xue X; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.
  • Panda S; Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA.
  • Kawale A; The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.
  • Hooy RM; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.
  • Liang F; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Sohn J; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.
  • Sung P; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Gekara NO; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.
EMBO J ; 38(21): e102718, 2019 10 04.
Article in En | MEDLINE | ID: mdl-31544964
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatin / Cell Nucleus / Cell Death / Genomic Instability / Recombinational DNA Repair / Nucleotidyltransferases Limits: Animals / Humans Language: En Journal: EMBO J Year: 2019 Type: Article Affiliation country: Sweden
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatin / Cell Nucleus / Cell Death / Genomic Instability / Recombinational DNA Repair / Nucleotidyltransferases Limits: Animals / Humans Language: En Journal: EMBO J Year: 2019 Type: Article Affiliation country: Sweden