Simultaneous quantification of tau and &#945;-synuclein in cerebrospinal fluid by high-resolution mass spectrometry for differentiation of Lewy Body Dementia from Alzheimer's Disease and controls.

Viodé, Arthur; Epelbaum, Stéphane; Benyounes, Imen; Verny, Marc; Dubois, Bruno; Junot, Christophe; Fenaille, François; Lamari, Foudil; Becher, François

Simultaneous quantification of tau and α-synuclein in cerebrospinal fluid by high-resolution mass spectrometry for differentiation of Lewy Body Dementia from Alzheimer's Disease and controls.

Viodé, Arthur; Epelbaum, Stéphane; Benyounes, Imen; Verny, Marc; Dubois, Bruno; Junot, Christophe; Fenaille, François; Lamari, Foudil; Becher, François.

Affiliation

Viodé A; Service de Pharmacologie et d'Immunoanalyse (SPI), Laboratoire d'Etude du Métabolisme des Médicaments (LEMM), CEA, INRA, Université Paris Saclay, F-91191 Gif-sur-Yvette cedex, France. francois.becher@cea.fr.

Analyst ; 144(21): 6342-6351, 2019 Oct 22.

Article in En | MEDLINE | ID: mdl-31553333

Subject(s)

Alzheimer Disease/diagnosis; Lewy Body Disease/diagnosis; alpha-Synuclein/cerebrospinal fluid; tau Proteins/cerebrospinal fluid; Amino Acid Sequence; Biomarkers/cerebrospinal fluid; Chromatography, Liquid; Diagnosis, Differential; Humans; Peptide Fragments/cerebrospinal fluid; Proteolysis; Serine Endopeptidases/chemistry; Tandem Mass Spectrometry; Trypsin/chemistry; alpha-Synuclein/chemistry; tau Proteins/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tau Proteins / Lewy Body Disease / Alpha-Synuclein / Alzheimer Disease Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Analyst Year: 2019 Type: Article Affiliation country: France

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