Photo-induced synthesis of Axinastatin 3 analogs, the secondary structures and their in vitro antitumor activities.

Bao, Yujun; Zhao, Lishuang; Wu, Jingwan; Jiang, Shitian; Wang, Zhiqiang; Jin, Yingxue

Bao, Yujun; Zhao, Lishuang; Wu, Jingwan; Jiang, Shitian; Wang, Zhiqiang; Jin, Yingxue.

Affiliation

Bao Y; Key Laboratory of Photochemistry Biomaterials and Energy Storage Materials of Heilongjiang Province, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Zhao L; Key Laboratory of Molecular Cytogenetics and Genetic Breeding of Heilongjiang Province, Harbin, College of Life Science and Technology, Harbin Normal University, Harbin 150025, China.
Wu J; Key Laboratory of Photochemistry Biomaterials and Energy Storage Materials of Heilongjiang Province, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Jiang S; Key Laboratory of Photochemistry Biomaterials and Energy Storage Materials of Heilongjiang Province, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Wang Z; Key Laboratory of Photochemistry Biomaterials and Energy Storage Materials of Heilongjiang Province, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China. Electronic address: wzq70402@163.com.
Jin Y; Key Laboratory of Photochemistry Biomaterials and Energy Storage Materials of Heilongjiang Province, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China. Electronic address: jyxprof@163.com.

Bioorg Med Chem Lett ; 29(22): 126730, 2019 11 15.

Article in En | MEDLINE | ID: mdl-31607609

Subject(s)

Peptides, Cyclic/pharmacology; Animals; Antineoplastic Agents; Cell Line; Cell Proliferation/drug effects; Density Functional Theory; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Electron Transport; Fibroblasts/drug effects; Humans; Mice; Models, Molecular; Molecular Conformation; Peptides, Cyclic/chemical synthesis; Peptides, Cyclic/chemistry; Photochemical Processes; Stereoisomerism; Structure-Activity Relationship

Key words

Antitumor activity; Cyclopeptide; Photo-induced; Synthesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Type: Article Affiliation country: China

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