Synaptic mitochondria regulate hair-cell synapse size and function.

Wong, Hiu-Tung C; Zhang, Qiuxiang; Beirl, Alisha J; Petralia, Ronald S; Wang, Ya-Xian; Kindt, Katie

Wong, Hiu-Tung C; Zhang, Qiuxiang; Beirl, Alisha J; Petralia, Ronald S; Wang, Ya-Xian; Kindt, Katie.

Affiliation

Wong HC; Section on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.
Zhang Q; National Institutes of Health-Johns Hopkins University Graduate Partnership Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.
Beirl AJ; Section on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.
Petralia RS; Section on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.
Wang YX; Advanced Imaging Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.
Kindt K; Advanced Imaging Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.

Elife ; 82019 10 14.

Article in En | MEDLINE | ID: mdl-31609202

Subject(s)

Calcium Channels, L-Type/metabolism; Calcium/metabolism; Evoked Potentials, Auditory/physiology; Eye Proteins/metabolism; Hair Cells, Auditory/metabolism; Mitochondria/metabolism; Synapses/metabolism; Zebrafish Proteins/metabolism; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester/pharmacology; Animals; Animals, Genetically Modified; Calcium Channel Agonists/pharmacology; Calcium Channel Blockers/pharmacology; Calcium Channels, L-Type/genetics; Calcium Signaling; Cell Size; Embryo, Nonmammalian; Eye Proteins/chemistry; Eye Proteins/genetics; Gene Expression; Hair Cells, Auditory/cytology; Hair Cells, Auditory/drug effects; Isradipine/pharmacology; Mitochondria/drug effects; Mitochondria/ultrastructure; NAD/metabolism; Oxidation-Reduction; Protein Binding; Protein Interaction Domains and Motifs; Ruthenium Compounds/pharmacology; Synapses/drug effects; Synapses/ultrastructure; Synaptic Transmission; Zebrafish; Zebrafish Proteins/agonists; Zebrafish Proteins/antagonists & inhibitors; Zebrafish Proteins/chemistry; Zebrafish Proteins/genetics

Key words

developmental biology; metabolism; mitochondrial calcium; neuroscience; ribbon synapse; sensory cell; zebrafish

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Calcium / Calcium Channels, L-Type / Zebrafish Proteins / Evoked Potentials, Auditory / Eye Proteins / Hair Cells, Auditory / Mitochondria Limits: Animals Language: En Journal: Elife Year: 2019 Type: Article Affiliation country: United States

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