Ratiometric GPCR signaling enables directional sensing in yeast.

Henderson, Nicholas T; Pablo, Michael; Ghose, Debraj; Clark-Cotton, Manuella R; Zyla, Trevin R; Nolen, James; Elston, Timothy C; Lew, Daniel J

Henderson, Nicholas T; Pablo, Michael; Ghose, Debraj; Clark-Cotton, Manuella R; Zyla, Trevin R; Nolen, James; Elston, Timothy C; Lew, Daniel J.

Affiliation

Henderson NT; Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, United States of America.
Pablo M; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Ghose D; Program in Molecular and Cellular Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Clark-Cotton MR; Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, United States of America.
Zyla TR; Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, United States of America.
Nolen J; Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, United States of America.
Elston TC; Department of Mathematics, Duke University, Durham, North Carolina, United States of America.
Lew DJ; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

PLoS Biol ; 17(10): e3000484, 2019 10.

Article in En | MEDLINE | ID: mdl-31622333

Subject(s)

Gene Expression Regulation, Fungal; Genes, Mating Type, Fungal; Pheromones/metabolism; Saccharomyces cerevisiae/genetics; Signal Transduction/genetics; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Cyclin-Dependent Kinase Inhibitor Proteins/genetics; Cyclin-Dependent Kinase Inhibitor Proteins/metabolism; Genes, Reporter; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Guanine Nucleotide Exchange Factors/genetics; Guanine Nucleotide Exchange Factors/metabolism; Receptors, Mating Factor/genetics; Receptors, Mating Factor/metabolism; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism; cdc42 GTP-Binding Protein, Saccharomyces cerevisiae/genetics; cdc42 GTP-Binding Protein, Saccharomyces cerevisiae/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pheromones / Saccharomyces cerevisiae / Signal Transduction / Gene Expression Regulation, Fungal / Genes, Mating Type, Fungal Language: En Journal: PLoS Biol Journal subject: BIOLOGIA Year: 2019 Type: Article Affiliation country: United States

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